The eukaryotic genome, its reads, and the unfinished assembly

José Fernando Muñoz, Juan Esteban Gallo, Elizabeth Misas, Juan Guillermo McEwen, Oliver Keatinge Clay

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

In recent years, readily affordable short read sequences provided by next-generation sequencing (NGS) have become longer and more accurate. This has led to a jump in interest in the utility of NGS-only approaches for exploring eukaryotic genomes. The concept of a static, 'finished' genome assembly, which still appears to be a faraway goal for many eukaryotes, is yielding to new paradigms. We here motivate an object-view concept where the raw reads are the main, fixed object, and assemblies with their annotations take a role of dynamically changing and modifiable views of that object.

Idioma originalInglés estadounidense
Páginas (desde-hasta)2090-2093
Número de páginas4
PublicaciónFEBS Letters
Volumen587
N.º14
DOI
EstadoPublicada - jul 11 2013

All Science Journal Classification (ASJC) codes

  • Biofísica
  • Biología estructural
  • Bioquímica
  • Biología molecular
  • Genética
  • Biología celular

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