The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity

A Systematic Review and Meta-Analysis

Katherine González-Ruiz, Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Mark D. Peterson, Antonio García-Hermoso

Resultado de la investigación: Contribución a RevistaArtículo

10 Citas (Scopus)

Resumen

Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95% confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95% CI, -0.976 to -0.346; p < 0.001), subcutaneous (SMD = -0.352; 95% CI, -0.517 to -0.186; p < 0.001) and intrahepatic fat (SMD = -0.802; 95% CI, -1.124 to -0.480; p < 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95% CI, -1.203 to -0.249; p < 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163.

Idioma originalEnglish (US)
Páginas (desde-hasta)272-282
Número de páginas11
PublicaciónChildhood Obesity
Volumen13
N.º4
DOI
EstadoPublished - ago 1 2017
Publicado de forma externa

Huella dactilar

Abdominal Fat
Pediatric Obesity
Meta-Analysis
Exercise
Liver
Enzymes
Confidence Intervals
Intra-Abdominal Fat
Subcutaneous Fat
Fats
Transferases
Obesity
Aspartate Aminotransferases
Alanine Transaminase
Disease Progression
Clinical Trials
Databases
Pediatrics
Lipids
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Citar esto

González-Ruiz, K., Ramírez-Vélez, R., Correa-Bautista, J. E., Peterson, M. D., & García-Hermoso, A. (2017). The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis. Childhood Obesity, 13(4), 272-282. https://doi.org/10.1089/chi.2017.0027
González-Ruiz, Katherine ; Ramírez-Vélez, Robinson ; Correa-Bautista, Jorge Enrique ; Peterson, Mark D. ; García-Hermoso, Antonio. / The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity : A Systematic Review and Meta-Analysis. En: Childhood Obesity. 2017 ; Vol. 13, N.º 4. pp. 272-282.
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abstract = "Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95{\%} confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95{\%} CI, -0.976 to -0.346; p < 0.001), subcutaneous (SMD = -0.352; 95{\%} CI, -0.517 to -0.186; p < 0.001) and intrahepatic fat (SMD = -0.802; 95{\%} CI, -1.124 to -0.480; p < 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95{\%} CI, -1.203 to -0.249; p < 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163.",
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González-Ruiz, K, Ramírez-Vélez, R, Correa-Bautista, JE, Peterson, MD & García-Hermoso, A 2017, 'The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis', Childhood Obesity, vol. 13, n.º 4, pp. 272-282. https://doi.org/10.1089/chi.2017.0027

The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity : A Systematic Review and Meta-Analysis. / González-Ruiz, Katherine; Ramírez-Vélez, Robinson; Correa-Bautista, Jorge Enrique; Peterson, Mark D.; García-Hermoso, Antonio.

En: Childhood Obesity, Vol. 13, N.º 4, 01.08.2017, p. 272-282.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - García-Hermoso, Antonio

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González-Ruiz K, Ramírez-Vélez R, Correa-Bautista JE, Peterson MD, García-Hermoso A. The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis. Childhood Obesity. 2017 ago 1;13(4):272-282. https://doi.org/10.1089/chi.2017.0027