The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis

JE Correa-Bautista, José F. Meneses-Echávez, Emilio González-Jiménez, Jacqueline Schmidt-RioValle, Mark R. Elkins, Felipe Lobelo, Robinson Ramírez-Vélez

Resultado de la investigación: Contribución a RevistaArtículo

20 Citas (Scopus)

Resumen

Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95% CI, -1.21 to -0.06), IL8 (MD = -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. Cancer Epidemiol Biomarkers Prev; 25(7); 1009-17.
Idioma originalEnglish (US)
Páginas (desde-hasta)1009 - 1017
Número de páginas9
PublicaciónMedicine and Science in Sports and Exercise
Volumen25
N.º7
DOI
EstadoPublished - jul 2016

Huella dactilar

Inflammation Mediators
Survivors
Confidence Intervals
Exercise
Breast Neoplasms
Tumor Microenvironment
Meta-Analysis
Tumor Biomarkers
Serum
Interleukin-8
Interleukin-10
C-Reactive Protein
Interleukin-2
Prescriptions
Interleukin-6
Randomized Controlled Trials
Inflammation
Population

Citar esto

Correa-Bautista, JE., Meneses-Echávez, J. F., González-Jiménez, E., Schmidt-RioValle, J., Elkins, M. R., Lobelo, F., & Ramírez-Vélez, R. (2016). The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis. Medicine and Science in Sports and Exercise, 25(7), 1009 - 1017. https://doi.org/10.1249/01.mss.0000486556.69698.52
Correa-Bautista, JE ; Meneses-Echávez, José F. ; González-Jiménez, Emilio ; Schmidt-RioValle, Jacqueline ; Elkins, Mark R. ; Lobelo, Felipe ; Ramírez-Vélez, Robinson. / The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis. En: Medicine and Science in Sports and Exercise. 2016 ; Vol. 25, N.º 7. pp. 1009 - 1017.
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title = "The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis",
abstract = "Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95{\%} confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95{\%} CI, -1.21 to -0.06), IL8 (MD = -0.49 pg/mL; 95{\%} CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95{\%} CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95{\%} CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95{\%} CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. Cancer Epidemiol Biomarkers Prev; 25(7); 1009-17.",
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Correa-Bautista, JE, Meneses-Echávez, JF, González-Jiménez, E, Schmidt-RioValle, J, Elkins, MR, Lobelo, F & Ramírez-Vélez, R 2016, 'The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis', Medicine and Science in Sports and Exercise, vol. 25, n.º 7, pp. 1009 - 1017. https://doi.org/10.1249/01.mss.0000486556.69698.52

The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis. / Correa-Bautista, JE; Meneses-Echávez, José F.; González-Jiménez, Emilio; Schmidt-RioValle, Jacqueline; Elkins, Mark R.; Lobelo, Felipe; Ramírez-Vélez, Robinson.

En: Medicine and Science in Sports and Exercise, Vol. 25, N.º 7, 07.2016, p. 1009 - 1017.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - The Effect of Exercise Training On Mediators of Inflammation In Breast Cancer Survivors: A Systematic Review With Metaanalysis

AU - Correa-Bautista, JE

AU - Meneses-Echávez, José F.

AU - González-Jiménez, Emilio

AU - Schmidt-RioValle, Jacqueline

AU - Elkins, Mark R.

AU - Lobelo, Felipe

AU - Ramírez-Vélez, Robinson

PY - 2016/7

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N2 - Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95% CI, -1.21 to -0.06), IL8 (MD = -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. Cancer Epidemiol Biomarkers Prev; 25(7); 1009-17.

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DO - 10.1249/01.mss.0000486556.69698.52

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