The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis

Jose F. Meneses-Echavez, Jorge E. Correa-Bautista, Emilio González-Jiménez, Jacqueline Schmidt Río-Valle, Mark R. Elkins, Felipe Lobelo, Robinson Ramírez-Velez

Resultado de la investigación: Contribución a RevistaArtículo de revisión

31 Citas (Scopus)

Resumen

Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.

Idioma originalEnglish (US)
Páginas (desde-hasta)1009-1017
Número de páginas9
PublicaciónCancer Epidemiology Biomarkers and Prevention
Volumen25
N.º7
DOI
EstadoPublished - jul 1 2016

Huella dactilar

Inflammation Mediators
Survivors
Meta-Analysis
Confidence Intervals
Exercise
Breast Neoplasms
Tumor Microenvironment
Serum
Interleukin-8
Interleukin-10
C-Reactive Protein
Interleukin-2
Prescriptions
Interleukin-6
Randomized Controlled Trials
Inflammation
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Citar esto

Meneses-Echavez, J. F., Correa-Bautista, J. E., González-Jiménez, E., Río-Valle, J. S., Elkins, M. R., Lobelo, F., & Ramírez-Velez, R. (2016). The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis. Cancer Epidemiology Biomarkers and Prevention, 25(7), 1009-1017. https://doi.org/10.1158/1055-9965.EPI-15-1061
Meneses-Echavez, Jose F. ; Correa-Bautista, Jorge E. ; González-Jiménez, Emilio ; Río-Valle, Jacqueline Schmidt ; Elkins, Mark R. ; Lobelo, Felipe ; Ramírez-Velez, Robinson. / The effect of exercise training on mediators of inflammation in breast cancer survivors : A systematic review with meta-analysis. En: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, N.º 7. pp. 1009-1017.
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abstract = "Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95{\%} confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95{\%}CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95{\%} CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95{\%} CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95{\%} CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95{\%} CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.",
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Meneses-Echavez, JF, Correa-Bautista, JE, González-Jiménez, E, Río-Valle, JS, Elkins, MR, Lobelo, F & Ramírez-Velez, R 2016, 'The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis', Cancer Epidemiology Biomarkers and Prevention, vol. 25, n.º 7, pp. 1009-1017. https://doi.org/10.1158/1055-9965.EPI-15-1061

The effect of exercise training on mediators of inflammation in breast cancer survivors : A systematic review with meta-analysis. / Meneses-Echavez, Jose F.; Correa-Bautista, Jorge E.; González-Jiménez, Emilio; Río-Valle, Jacqueline Schmidt; Elkins, Mark R.; Lobelo, Felipe; Ramírez-Velez, Robinson.

En: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, N.º 7, 01.07.2016, p. 1009-1017.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

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T1 - The effect of exercise training on mediators of inflammation in breast cancer survivors

T2 - A systematic review with meta-analysis

AU - Meneses-Echavez, Jose F.

AU - Correa-Bautista, Jorge E.

AU - González-Jiménez, Emilio

AU - Río-Valle, Jacqueline Schmidt

AU - Elkins, Mark R.

AU - Lobelo, Felipe

AU - Ramírez-Velez, Robinson

PY - 2016/7/1

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N2 - Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.

AB - Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population.

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