The autoimmune tautology: An in silico approach

Ricardo A. Cifuentes, Daniel Restrepo-Montoya, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sj°grens syndromesystemic lupus erythematosus, and autoimmune thyroid diseasetype1 diabetesrheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10. © Copyright 2012 Ricardo A. Cifuentes et al.
Idioma originalEnglish (US)
PublicaciónAutoimmune Diseases
DOI
EstadoPublished - abr 3 2012

Huella dactilar

Computer Simulation
Autoimmune Diseases
Genetic Phenomena
Genes
Proteins
Data Mining
Interleukin-10
Arthritis
Thyroid Gland
Apoptosis

Citar esto

Cifuentes, Ricardo A. ; Restrepo-Montoya, Daniel ; Anaya, Juan Manuel. / The autoimmune tautology: An in silico approach. En: Autoimmune Diseases. 2012.
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The autoimmune tautology: An in silico approach. / Cifuentes, Ricardo A.; Restrepo-Montoya, Daniel; Anaya, Juan Manuel.

En: Autoimmune Diseases, 03.04.2012.

Resultado de la investigación: Contribución a RevistaArtículo

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