The autoimmune tautology

Juan Manuel Anaya

Producción científica: Contribución a una revistaEditorialrevisión exhaustiva

78 Citas (Scopus)

Resumen

Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

Idioma originalInglés estadounidense
Número de artículo147
PublicaciónArthritis Research and Therapy
Volumen12
N.º6
DOI
EstadoPublicada - sep. 9 2010

Áreas temáticas de ASJC Scopus

  • Reumatología
  • Inmulogía y alergología
  • Inmunología

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