The autoimmune tautology

Resultado de la investigación: Contribución a RevistaArtículo de revisión

50 Citas (Scopus)

Resumen

Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

Idioma originalEnglish (US)
Páginas (desde-hasta)147
PublicaciónArthritis Research and Therapy
Volumen12
N.º6
DOI
EstadoPublished - 2010

Huella dactilar

Autoimmune Diseases
Immunogenetics
Clinical Pathology
Nuclear Family
Autoimmunity
Phenotype
Genes

Citar esto

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The autoimmune tautology. / Anaya, Juan-Manuel.

En: Arthritis Research and Therapy, Vol. 12, N.º 6, 2010, p. 147.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

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AU - Anaya, Juan-Manuel

PY - 2010

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N2 - Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

AB - Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

U2 - 10.1186/ar3175

DO - 10.1186/ar3175

M3 - Review article

VL - 12

SP - 147

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

SN - 1478-6354

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