Tetralogy of Fallot Repair in Developing Countries: International Quality Improvement Collaborative

Nestor Sandoval, Marisol Carreño, William M. Novick, Ravi Agarwal, Iftikhar Ahmed, Rakhi Balachandran, Maria Balestrini, K. M. Cherian, Ulisses Croti, Xinwei Du, Kimberlee Gauvreau, Do Thi Cam Giang, Ramkinkar Shastri, Kathy J. Jenkins

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)


Isolated reports from low- and middle-income countries (LMICs) for surgical results in tetralogy of Fallot (TOF) are available. The International Quality Improvement Collaborative for Congenital Heart Disease (IQIC) seeks to improve surgical results promoting reductions in infection and mortality in LMICs.

All cases of TOF in the IQIC database performed between 2010 and 2014 at 32 centers in 20 LMICs were included. Excluded from the analysis were TOF with any associated lesions. A logistic regression analysis was performed to identify risk factors for in-hospital mortality after surgery for TOF.

A total of 2,164 patients were identified. There were 1,839 initial primary repairs, 200 with initial systemic-to-pulmonary artery shunt, and 125 underwent secondary repair after initial palliation. Overall mortality was 3.6% (78 of 2,164), initial primary repair was 3.3% (60 of 1,839), initial systemic-to-pulmonary artery shunt was 8.0% (16 of 200), and secondary repair was 1.6% (2 of 125; p = 0.003). Major infections occurred in 5.9% (128 of 2,164) of the entire cohort. Risk factors for death after the initial primary repair were oxygen saturation less than 90% and weight/body mass index for age below the fifth percentile ( p < 0.001). The initial primary repair occurred after age 1 year in 54% (991 of 1,839). Older age at initial primary repair was not a risk factor for death ( p = 0.21).

TOF patients are often operated on after age 1 year in LMICs. Unlike in developed countries, older age is not a risk factor for death. Nutritional and hypoxemic status were associated with higher mortality and infection. This information fills a critical knowledge gap for surgery in LMIC.
Idioma originalInglés estadounidense
Páginas (desde-hasta)1446-1451
Número de páginas6
PublicaciónAnnals of Thoracic Surgery
EstadoPublicada - nov. 2018
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Cirugía
  • Neumología
  • Cardiología y medicina cardiovascular


Profundice en los temas de investigación de 'Tetralogy of Fallot Repair in Developing Countries: International Quality Improvement Collaborative'. En conjunto forman una huella única.

Citar esto