Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions

Diego H Cáceres; Beatriz L Gómez; Ángela M Tobón; Ángela Restrepo; Tom Chiller; Mark D Lindsley; Jacques F Meis; Paul E Verweij

doi:10.3390/jof9050558

Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions

Diego H Cáceres
, Beatriz L Gómez
, Ángela M Tobón
, Ángela Restrepo
, Tom Chiller
, Mark D Lindsley
, Jacques F Meis
, Paul E Verweij

Producción científica: Contribución a revista › Artículo de revisión › revisión exhaustiva

13 Citas (Scopus)

Resumen

La histoplasmosis, causada por el hongo térmicamente dimórfico Histoplasma spp., es una enfermedad con un amplio espectro clínico, que se presenta desde síntomas asintomáticos/similables a los de la gripe hasta enfermedad diseminada progresiva en personas con inmunodepresión. En los últimos años, el concepto de histoplasmosis como una enfermedad restringida al continente americano ha cambiado, ya que ahora la histoplasmosis se registra en muchas regiones de todo el mundo. En América Latina, la histoplasmosis representa una amenaza, especialmente en personas con enfermedad avanzada por VIH (EHA). El diagnóstico de la histoplasmosis en personas que viven con el VIH (PVVIH) es difícil debido al bajo índice de sospecha de la enfermedad, la inespecificidad de los signos y síntomas y el acceso limitado a pruebas de laboratorio específicas, mientras que el retraso diagnóstico se asocia significativamente con la mortalidad. En la última década se han desarrollado nuevas pruebas diagnósticas para la detección rápida de la histoplasmosis, como los kits comerciales para la detección de antígenos. Además, se crearon grupos de defensa que presentaban la histoplasmosis como un problema de salud pública, haciendo hincapié en los pacientes con riesgo de enfermedad diseminada progresiva. El objetivo de esta revisión es discutir el impacto de la histoplasmosis asociada a la EHA en América Latina y las estrategias empleadas para enfrentar la histoplasmosis, desde la implementación de pruebas de laboratorio hasta la promoción de la enfermedad y las intervenciones de salud pública.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1
Número de páginas	15
Publicación	Journal of Fungi
Volumen	9
N.º	5
DOI	https://doi.org/10.3390/jof9050558
Estado	Publicada - may. 11 2023

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Microbiología (médica)

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@article{c644dd5691bf442aba837b043e46131f,

title = "Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions",

abstract = "Histoplasmosis, caused by the thermally dimorphic fungus Histoplasma spp., is a disease with a broad clinical spectrum, presenting from asymptomatic/flu-like symptoms to progressive disseminated disease in people with immunosuppression. In recent years, the concept of histoplasmosis as a disease restricted to the American continent has changed, as now histoplasmosis is reported in many regions around the world. In Latin America, histoplasmosis represents a threat, especially in people with advanced HIV disease (AHD). Diagnosis of histoplasmosis in people living with HIV (PLHIV) is challenging due to the low index of suspicion of the disease, non-specificity of signs and symptoms, and limited access to specific laboratory testing, while the diagnostic delay is significantly associated with mortality. In the last decade, novel diagnostic tests have been developed for the rapid detection of histoplasmosis, such as commercial kits for antigen detection. Furthermore, advocacy groups were created that presented histoplasmosis as a public health problem, with emphasis on patients at risk of progressive disseminated disease. This review aims to discuss the impact of histoplasmosis associated with AHD in Latin America and the strategies employed to tackle histoplasmosis, from the implementation of laboratory testing to disease advocacy and public health interventions.",

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AU - Cáceres, Diego H

AU - Gómez, Beatriz L

AU - Tobón, Ángela M

AU - Restrepo, Ángela

AU - Chiller, Tom

AU - Lindsley, Mark D

AU - Meis, Jacques F

AU - Verweij, Paul E

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N2 - Histoplasmosis, caused by the thermally dimorphic fungus Histoplasma spp., is a disease with a broad clinical spectrum, presenting from asymptomatic/flu-like symptoms to progressive disseminated disease in people with immunosuppression. In recent years, the concept of histoplasmosis as a disease restricted to the American continent has changed, as now histoplasmosis is reported in many regions around the world. In Latin America, histoplasmosis represents a threat, especially in people with advanced HIV disease (AHD). Diagnosis of histoplasmosis in people living with HIV (PLHIV) is challenging due to the low index of suspicion of the disease, non-specificity of signs and symptoms, and limited access to specific laboratory testing, while the diagnostic delay is significantly associated with mortality. In the last decade, novel diagnostic tests have been developed for the rapid detection of histoplasmosis, such as commercial kits for antigen detection. Furthermore, advocacy groups were created that presented histoplasmosis as a public health problem, with emphasis on patients at risk of progressive disseminated disease. This review aims to discuss the impact of histoplasmosis associated with AHD in Latin America and the strategies employed to tackle histoplasmosis, from the implementation of laboratory testing to disease advocacy and public health interventions.

AB - Histoplasmosis, caused by the thermally dimorphic fungus Histoplasma spp., is a disease with a broad clinical spectrum, presenting from asymptomatic/flu-like symptoms to progressive disseminated disease in people with immunosuppression. In recent years, the concept of histoplasmosis as a disease restricted to the American continent has changed, as now histoplasmosis is reported in many regions around the world. In Latin America, histoplasmosis represents a threat, especially in people with advanced HIV disease (AHD). Diagnosis of histoplasmosis in people living with HIV (PLHIV) is challenging due to the low index of suspicion of the disease, non-specificity of signs and symptoms, and limited access to specific laboratory testing, while the diagnostic delay is significantly associated with mortality. In the last decade, novel diagnostic tests have been developed for the rapid detection of histoplasmosis, such as commercial kits for antigen detection. Furthermore, advocacy groups were created that presented histoplasmosis as a public health problem, with emphasis on patients at risk of progressive disseminated disease. This review aims to discuss the impact of histoplasmosis associated with AHD in Latin America and the strategies employed to tackle histoplasmosis, from the implementation of laboratory testing to disease advocacy and public health interventions.

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Tackling Histoplasmosis Infection in People Living with HIV from Latin America: From Diagnostic Strategy to Public Health Solutions

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