Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus

G. Orozco, E. Sánchez, L. M. Gómez, M. A. González-Gay, M. A. López-Nevot, B. Torres, N. Ortego-Centeno, J. Jiménez-Alonso, E. De Ramón, J. Sánchez Román, J. M. Anaya, G. Sturfelt, I. Gunnarsson, E. Svennungsson, M. Alarcón-Riquelme, M. F. González-Escribano, Javier Martín

Resultado de la investigación: Contribución a RevistaArtículo

12 Citas (Scopus)

Resumen

Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO-4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that common genetic bases are shared by autoimmune disorders. Methods: 597 SLE patients and 987 healthy controls of white Spanish origin were studied. Two additional cohorts of 228 SLE patients from Sweden and 122 SLE patients from Colombia were included. A case-control association study was carried out with six single nucleotide polymorphisms (SNP) spanning the SLC22A4 gene, one SNP in RUNX1 gene, and one additional SNP in SUM04 gene. Results: No significant differences were observed between SLE patients and healthy controls when comparing the distribution of the genotypes or alleles of any of the SLC22A4, RUNX1, or SUMO4 polymorphisms tested. Significant differences were found in the distribution of the SUMO4 genotypes and alleles among SLE patients with and without nephritis, but after multiple testing correction, the significance of the association was lost. The association of SUMO4 with nephritis could not be verified in two independent SLE cohorts from Sweden and Colombia. Conclusions: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analysed do not play a role in the susceptibility to or severity of SLE.
Idioma originalEnglish (US)
Páginas (desde-hasta)791-795
Número de páginas5
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublished - jun 1 2006

Huella dactilar

Polymorphism
Systemic Lupus Erythematosus
Genes
Nucleotides
Single Nucleotide Polymorphism
Core Binding Factor Alpha 2 Subunit
Colombia
Nephritis
Sweden
Alleles
Genotype
Modifier Genes
Ubiquitin
Autoimmune Diseases
Case-Control Studies
Testing

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Orozco, G., Sánchez, E., Gómez, L. M., González-Gay, M. A., López-Nevot, M. A., Torres, B., ... Martín, J. (2006). Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 791-795. https://doi.org/10.1136/ard.2005.044891
Orozco, G. ; Sánchez, E. ; Gómez, L. M. ; González-Gay, M. A. ; López-Nevot, M. A. ; Torres, B. ; Ortego-Centeno, N. ; Jiménez-Alonso, J. ; De Ramón, E. ; Sánchez Román, J. ; Anaya, J. M. ; Sturfelt, G. ; Gunnarsson, I. ; Svennungsson, E. ; Alarcón-Riquelme, M. ; González-Escribano, M. F. ; Martín, Javier. / Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus. En: Annals of the Rheumatic Diseases. 2006 ; pp. 791-795.
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title = "Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus",
abstract = "Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO-4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that common genetic bases are shared by autoimmune disorders. Methods: 597 SLE patients and 987 healthy controls of white Spanish origin were studied. Two additional cohorts of 228 SLE patients from Sweden and 122 SLE patients from Colombia were included. A case-control association study was carried out with six single nucleotide polymorphisms (SNP) spanning the SLC22A4 gene, one SNP in RUNX1 gene, and one additional SNP in SUM04 gene. Results: No significant differences were observed between SLE patients and healthy controls when comparing the distribution of the genotypes or alleles of any of the SLC22A4, RUNX1, or SUMO4 polymorphisms tested. Significant differences were found in the distribution of the SUMO4 genotypes and alleles among SLE patients with and without nephritis, but after multiple testing correction, the significance of the association was lost. The association of SUMO4 with nephritis could not be verified in two independent SLE cohorts from Sweden and Colombia. Conclusions: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analysed do not play a role in the susceptibility to or severity of SLE.",
author = "G. Orozco and E. S{\'a}nchez and G{\'o}mez, {L. M.} and Gonz{\'a}lez-Gay, {M. A.} and L{\'o}pez-Nevot, {M. A.} and B. Torres and N. Ortego-Centeno and J. Jim{\'e}nez-Alonso and {De Ram{\'o}n}, E. and {S{\'a}nchez Rom{\'a}n}, J. and Anaya, {J. M.} and G. Sturfelt and I. Gunnarsson and E. Svennungsson and M. Alarc{\'o}n-Riquelme and Gonz{\'a}lez-Escribano, {M. F.} and Javier Mart{\'i}n",
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Orozco, G, Sánchez, E, Gómez, LM, González-Gay, MA, López-Nevot, MA, Torres, B, Ortego-Centeno, N, Jiménez-Alonso, J, De Ramón, E, Sánchez Román, J, Anaya, JM, Sturfelt, G, Gunnarsson, I, Svennungsson, E, Alarcón-Riquelme, M, González-Escribano, MF & Martín, J 2006, 'Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus', Annals of the Rheumatic Diseases, pp. 791-795. https://doi.org/10.1136/ard.2005.044891

Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus. / Orozco, G.; Sánchez, E.; Gómez, L. M.; González-Gay, M. A.; López-Nevot, M. A.; Torres, B.; Ortego-Centeno, N.; Jiménez-Alonso, J.; De Ramón, E.; Sánchez Román, J.; Anaya, J. M.; Sturfelt, G.; Gunnarsson, I.; Svennungsson, E.; Alarcón-Riquelme, M.; González-Escribano, M. F.; Martín, Javier.

En: Annals of the Rheumatic Diseases, 01.06.2006, p. 791-795.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus

AU - Orozco, G.

AU - Sánchez, E.

AU - Gómez, L. M.

AU - González-Gay, M. A.

AU - López-Nevot, M. A.

AU - Torres, B.

AU - Ortego-Centeno, N.

AU - Jiménez-Alonso, J.

AU - De Ramón, E.

AU - Sánchez Román, J.

AU - Anaya, J. M.

AU - Sturfelt, G.

AU - Gunnarsson, I.

AU - Svennungsson, E.

AU - Alarcón-Riquelme, M.

AU - González-Escribano, M. F.

AU - Martín, Javier

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO-4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that common genetic bases are shared by autoimmune disorders. Methods: 597 SLE patients and 987 healthy controls of white Spanish origin were studied. Two additional cohorts of 228 SLE patients from Sweden and 122 SLE patients from Colombia were included. A case-control association study was carried out with six single nucleotide polymorphisms (SNP) spanning the SLC22A4 gene, one SNP in RUNX1 gene, and one additional SNP in SUM04 gene. Results: No significant differences were observed between SLE patients and healthy controls when comparing the distribution of the genotypes or alleles of any of the SLC22A4, RUNX1, or SUMO4 polymorphisms tested. Significant differences were found in the distribution of the SUMO4 genotypes and alleles among SLE patients with and without nephritis, but after multiple testing correction, the significance of the association was lost. The association of SUMO4 with nephritis could not be verified in two independent SLE cohorts from Sweden and Colombia. Conclusions: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analysed do not play a role in the susceptibility to or severity of SLE.

AB - Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO-4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that common genetic bases are shared by autoimmune disorders. Methods: 597 SLE patients and 987 healthy controls of white Spanish origin were studied. Two additional cohorts of 228 SLE patients from Sweden and 122 SLE patients from Colombia were included. A case-control association study was carried out with six single nucleotide polymorphisms (SNP) spanning the SLC22A4 gene, one SNP in RUNX1 gene, and one additional SNP in SUM04 gene. Results: No significant differences were observed between SLE patients and healthy controls when comparing the distribution of the genotypes or alleles of any of the SLC22A4, RUNX1, or SUMO4 polymorphisms tested. Significant differences were found in the distribution of the SUMO4 genotypes and alleles among SLE patients with and without nephritis, but after multiple testing correction, the significance of the association was lost. The association of SUMO4 with nephritis could not be verified in two independent SLE cohorts from Sweden and Colombia. Conclusions: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analysed do not play a role in the susceptibility to or severity of SLE.

U2 - 10.1136/ard.2005.044891

DO - 10.1136/ard.2005.044891

M3 - Article

SP - 791

EP - 795

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -