Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development

Manuel Elkin Patarroyo, Adriana Bermúdez, Manuel Alfonso Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

51 Citas (Scopus)

Resumen

Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules.
Idioma originalEnglish (US)
Páginas (desde-hasta)3459-3507
Número de páginas49
PublicaciónChemical Reviews
Volumen111
N.º5
DOI
EstadoPublished - 2011

Huella dactilar

Vaccines
Malaria Vaccines
Molecules
Gene encoding
Molecular interactions
Cloning
Immune system
Antimalarials
Immunoglobulins
Cytokines
Peptides
Proteins
Hepatocytes

Citar esto

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Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development. / Patarroyo, Manuel Elkin; Bermúdez, Adriana; Patarroyo, Manuel Alfonso.

En: Chemical Reviews, Vol. 111, N.º 5, 2011, p. 3459-3507.

Resultado de la investigación: Contribución a RevistaArtículo

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