Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans

Carlos F Suárez, Laura Pabón, Ana Barrera, Jorge Aza-Conde, Manuel Alfonso Patarroyo, Manuel Elkin Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

More than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainly antibody-mediated and controlled by the HLA-DRB genetic region, ∼1000 Aotus have been molecularly characterised for MHC-DRB, revealing striking similarity between human and Aotus MHC-DRB repertories. Such convergence suggested that a large group of immune protection-inducing protein structures (IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge in Aotus, could easily be used in humans for inducing full protection against malaria. We highlight the value of a logical and rational methodology for developing a vaccine in an appropriate animal model: Aotus monkeys.

Idioma originalEnglish (US)
Páginas (desde-hasta)1062-1069
Número de páginas8
PublicaciónBiochemical and Biophysical Research Communications
Volumen491
N.º4
DOI
EstadoPublished - sep 30 2017
Publicado de forma externa

Huella dactilar

Aotidae
Dichlororibofuranosylbenzimidazole
Malaria Vaccines
Major Histocompatibility Complex
Structural analysis
Malaria
Animals
Vaccines
Haplorhini
Immunity
Peptides
Parasites
Molecules
Theoretical Models
Animal Models
Antibodies
Proteins

Citar esto

Suárez, Carlos F ; Pabón, Laura ; Barrera, Ana ; Aza-Conde, Jorge ; Patarroyo, Manuel Alfonso ; Patarroyo, Manuel Elkin. / Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans. En: Biochemical and Biophysical Research Communications. 2017 ; Vol. 491, N.º 4. pp. 1062-1069.
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abstract = "More than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainly antibody-mediated and controlled by the HLA-DRB genetic region, ∼1000 Aotus have been molecularly characterised for MHC-DRB, revealing striking similarity between human and Aotus MHC-DRB repertories. Such convergence suggested that a large group of immune protection-inducing protein structures (IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge in Aotus, could easily be used in humans for inducing full protection against malaria. We highlight the value of a logical and rational methodology for developing a vaccine in an appropriate animal model: Aotus monkeys.",
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Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans. / Suárez, Carlos F; Pabón, Laura; Barrera, Ana; Aza-Conde, Jorge; Patarroyo, Manuel Alfonso; Patarroyo, Manuel Elkin.

En: Biochemical and Biophysical Research Communications, Vol. 491, N.º 4, 30.09.2017, p. 1062-1069.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans

AU - Suárez, Carlos F

AU - Pabón, Laura

AU - Barrera, Ana

AU - Aza-Conde, Jorge

AU - Patarroyo, Manuel Alfonso

AU - Patarroyo, Manuel Elkin

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/9/30

Y1 - 2017/9/30

N2 - More than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainly antibody-mediated and controlled by the HLA-DRB genetic region, ∼1000 Aotus have been molecularly characterised for MHC-DRB, revealing striking similarity between human and Aotus MHC-DRB repertories. Such convergence suggested that a large group of immune protection-inducing protein structures (IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge in Aotus, could easily be used in humans for inducing full protection against malaria. We highlight the value of a logical and rational methodology for developing a vaccine in an appropriate animal model: Aotus monkeys.

AB - More than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans). Since malarial immunity is mainly antibody-mediated and controlled by the HLA-DRB genetic region, ∼1000 Aotus have been molecularly characterised for MHC-DRB, revealing striking similarity between human and Aotus MHC-DRB repertories. Such convergence suggested that a large group of immune protection-inducing protein structures (IMPIPS), highly immunogenic and protection inducers against malarial intravenous challenge in Aotus, could easily be used in humans for inducing full protection against malaria. We highlight the value of a logical and rational methodology for developing a vaccine in an appropriate animal model: Aotus monkeys.

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