Staurosporine-induced apoptosis in P388D1 macrophages involves both extrinsic and intrinsic pathways

Yuko Nakamura-López, Rosa Elena Sarmiento-Silva, Julio Moran-Andrade, Beatriz Gómez-García

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Treatment of P388D1, a macrophage-like cell line, with staurosporine triggered apoptosis through the activation of caspase-9 and caspase-3. Unexpected effects of staurosporine on the induction of apoptosis were the activation of caspase-8, and an increase of the levels of TNF-α. The increased TNF-α levels led to activation of caspase-8 by an autocrine effect via the TNF receptor expressed by the P388D1 macrophages. In contrast, P388D1 macrophages that either had been exposed to UV light or treated with dexamethasone did not undergo apoptosis.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1026-1031
Número de páginas6
PublicaciónCell Biology International
Volumen33
N.º9
DOI
EstadoPublicada - sep. 2009
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Biología celular

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