Specific β-turns precede PPIIL structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components

Adriana Bermudez, Martha P. Alba, Magnolia Vanegas, Manuel A. Patarroyo, Manuel E. Patarroyo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

Idioma originalInglés estadounidense
Número de artículo106
PublicaciónFrontiers in Chemistry
Volumen6
N.ºAPR
DOI
EstadoPublicada - abr 1 2018

All Science Journal Classification (ASJC) codes

  • Química (todo)

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Profundice en los temas de investigación de 'Specific β-turns precede PPII<sub>L</sub> structures binding to allele-specific HLA-DRβ1* PBRs in fully-protective malaria vaccine components'. En conjunto forman una huella única.

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