Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

Adriana Bermudez, Martha P Alba, Magnolia Vanegas, Manuel A Patarroyo, Manuel E Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

Resumen

El análisis estructural 3D de 62 péptidos derivados de Plasmodium altamente patogénico
falciparum malaria parásito proteínas implicadas en la invasión de las células huéspedes llevó a encontrar un
sorprendente asociación entre tipos particulares de β-turn ubicados en la periferia de la terminal N
región de residuos adyacente (que precede a las estructuras zurdas de poliprolina II que encajan en
el HLA-DRβ
∗ familia de los alelos) y estructura proteica modificada que induce protección inmunológica
indujo una inmunidad protectora de larga duración. Esta es la primera vez que se asocia entre dos
diferentes estructuras secundarias asociadas con una función inmunológica específica ha
se ha descrito: inmunidad protectora completa y duradera.
Idioma originalEnglish (US)
Páginas (desde-hasta)106
Número de páginas10
PublicaciónFrontiers in Chemistry
Volumen6
DOI
EstadoPublished - abr 6 2018

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title = "Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components",
abstract = "The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.",
author = "Adriana Bermudez and Alba, {Martha P} and Magnolia Vanegas and Patarroyo, {Manuel A} and Patarroyo, {Manuel E}",
year = "2018",
month = "4",
day = "6",
doi = "10.3389/fchem.2018.00106",
language = "English (US)",
volume = "6",
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journal = "Frontiers in Chemistry",
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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components. / Bermudez, Adriana; Alba, Martha P; Vanegas, Magnolia; Patarroyo, Manuel A; Patarroyo, Manuel E.

En: Frontiers in Chemistry, Vol. 6, 06.04.2018, p. 106.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

AU - Bermudez, Adriana

AU - Alba, Martha P

AU - Vanegas, Magnolia

AU - Patarroyo, Manuel A

AU - Patarroyo, Manuel E

PY - 2018/4/6

Y1 - 2018/4/6

N2 - The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

AB - The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

U2 - 10.3389/fchem.2018.00106

DO - 10.3389/fchem.2018.00106

M3 - Article

VL - 6

SP - 106

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

SN - 2296-2646

ER -