Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases

Manuel Ramos-Casals, Veronique Loustaud-Ratti, Salvatore De Vita, Margit Zeher, Jose Angel Bosch, Eric Toussirot, Francisco Medina, Jose Rosas, Juan Manuel Anaya, Josep Font

Resultado de la investigación: Contribución a RevistaArtículo

134 Citas (Scopus)

Resumen

To define the clinical and immunologic pattern of expression of Sjoegren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCV-RNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive anti-Ro /SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS.In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term SS secondary to HCV when these patients fulfill the 2002 classification criteria for SS

Huella dactilar

Hepacivirus
Virus Diseases
Chronic Hepatitis C
Vasculitis
Cryoglobulins
Cryoglobulinemia
Rheumatoid Factor
Antinuclear Antibodies
European Union
Serology
DNA-Directed RNA Polymerases
Multicenter Studies
Hepatocellular Carcinoma
Neoplasms
Joints
Viruses
Polymerase Chain Reaction

Citar esto

Ramos-Casals, Manuel ; Loustaud-Ratti, Veronique ; De Vita, Salvatore ; Zeher, Margit ; Bosch, Jose Angel ; Toussirot, Eric ; Medina, Francisco ; Rosas, Jose ; Anaya, Juan Manuel ; Font, Josep. / Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases. En: Medicine; analytical.reviews of general medicine neurology psychiatry dermatology and pediatrics, {Medicine (Baltimore)}, Mar.2005, vol.84., no.2, p.81.9, ISSN.: 0025.7974. 2005 ; Vol. 84, N.º 2. pp. 81-89.
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title = "Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases",
abstract = "To define the clinical and immunologic pattern of expression of Sjoegren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCV-RNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58{\%}) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44{\%}), vasculitis (20{\%}), and neuropathy (16{\%}) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65{\%}), hypocomplementemia (51{\%}), and cryoglobulinemia (50{\%}). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23{\%}) patients had positive anti-Ro /SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14{\%}) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS.In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term SS secondary to HCV when these patients fulfill the 2002 classification criteria for SS",
author = "Manuel Ramos-Casals and Veronique Loustaud-Ratti and {De Vita}, Salvatore and Margit Zeher and Bosch, {Jose Angel} and Eric Toussirot and Francisco Medina and Jose Rosas and Anaya, {Juan Manuel} and Josep Font",
year = "2005",
month = "3",
doi = "10.1097/01.md.0000157397.30055.c9",
language = "English (US)",
volume = "84",
pages = "81--89",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
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Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases. / Ramos-Casals, Manuel; Loustaud-Ratti, Veronique; De Vita, Salvatore; Zeher, Margit; Bosch, Jose Angel; Toussirot, Eric; Medina, Francisco; Rosas, Jose; Anaya, Juan Manuel; Font, Josep.

En: Medicine; analytical.reviews of general medicine neurology psychiatry dermatology and pediatrics, {Medicine (Baltimore)}, Mar.2005, vol.84., no.2, p.81.9, ISSN.: 0025.7974., Vol. 84, N.º 2, 03.2005, p. 81-89.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases

AU - Ramos-Casals, Manuel

AU - Loustaud-Ratti, Veronique

AU - De Vita, Salvatore

AU - Zeher, Margit

AU - Bosch, Jose Angel

AU - Toussirot, Eric

AU - Medina, Francisco

AU - Rosas, Jose

AU - Anaya, Juan Manuel

AU - Font, Josep

PY - 2005/3

Y1 - 2005/3

N2 - To define the clinical and immunologic pattern of expression of Sjoegren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCV-RNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive anti-Ro /SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS.In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term SS secondary to HCV when these patients fulfill the 2002 classification criteria for SS

AB - To define the clinical and immunologic pattern of expression of Sjoegren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCV-RNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive anti-Ro /SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS.In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term SS secondary to HCV when these patients fulfill the 2002 classification criteria for SS

U2 - 10.1097/01.md.0000157397.30055.c9

DO - 10.1097/01.md.0000157397.30055.c9

M3 - Article

VL - 84

SP - 81

EP - 89

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 2

ER -