Screening for mutations of the FOXO4 gene in premature ovarian failure patients

Dora Janeth Fonseca, Eliana Garzón, Besma Lakhal, Rim Braham, Diego Ojeda, Hatem Elghezal, Ali Saâd, Carlos Martín Restrepo, Paul Laissue

Resultado de la investigación: Contribución a RevistaArtículo

6 Citas (Scopus)

Resumen

FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)339-341
Número de páginas3
PublicaciónReproductive BioMedicine Online
DOI
EstadoPublished - mar 1 2012

Huella dactilar

Primary Ovarian Insufficiency
Mutation
Open Reading Frames
Genes
Exons
Delivery of Health Care
Population

Citar esto

Fonseca, Dora Janeth ; Garzón, Eliana ; Lakhal, Besma ; Braham, Rim ; Ojeda, Diego ; Elghezal, Hatem ; Saâd, Ali ; Restrepo, Carlos Martín ; Laissue, Paul. / Screening for mutations of the FOXO4 gene in premature ovarian failure patients. En: Reproductive BioMedicine Online. 2012 ; pp. 339-341.
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abstract = "FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. {\circledC} 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
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Fonseca, DJ, Garzón, E, Lakhal, B, Braham, R, Ojeda, D, Elghezal, H, Saâd, A, Restrepo, CM & Laissue, P 2012, 'Screening for mutations of the FOXO4 gene in premature ovarian failure patients', Reproductive BioMedicine Online, pp. 339-341. https://doi.org/10.1016/j.rbmo.2011.11.017

Screening for mutations of the FOXO4 gene in premature ovarian failure patients. / Fonseca, Dora Janeth; Garzón, Eliana; Lakhal, Besma; Braham, Rim; Ojeda, Diego; Elghezal, Hatem; Saâd, Ali; Restrepo, Carlos Martín; Laissue, Paul.

En: Reproductive BioMedicine Online, 01.03.2012, p. 339-341.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Screening for mutations of the FOXO4 gene in premature ovarian failure patients

AU - Fonseca, Dora Janeth

AU - Garzón, Eliana

AU - Lakhal, Besma

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AU - Ojeda, Diego

AU - Elghezal, Hatem

AU - Saâd, Ali

AU - Restrepo, Carlos Martín

AU - Laissue, Paul

PY - 2012/3/1

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AB - FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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