TY - JOUR
T1 - Screening for mutations of the FOXO4 gene in premature ovarian failure patients
AU - Fonseca, Dora Janeth
AU - Garzón, Eliana
AU - Lakhal, Besma
AU - Braham, Rim
AU - Ojeda, Diego
AU - Elghezal, Hatem
AU - Saâd, Ali
AU - Restrepo, Carlos Martín
AU - Laissue, Paul
PY - 2012/3/1
Y1 - 2012/3/1
N2 - FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
AB - FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.rbmo.2011.11.017
DO - 10.1016/j.rbmo.2011.11.017
M3 - Article
C2 - 22285440
SN - 1472-6483
SP - 339
EP - 341
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
ER -