Safety in the acute management of migraine during pregnancy: A sistematic Review

Paola Andrea Ortiz Salas; Carlos Eduardo Pinzón Flórez; Ángela María Gutiérrez-Álvarez; Fidel Ernesto Sobrino Mejía

Safety in the acute management of migraine during pregnancy: A sistematic Review

Título traducido de la contribución: Seguridad en el tratamiento de la migraña aguda durante el embarazo: una revisión sistemática

Paola Andrea Ortiz Salas
, Carlos Eduardo Pinzón Flórez
, Ángela María Gutiérrez-Álvarez
, Fidel Ernesto Sobrino Mejía

Escuela de Medicina y Ciencias de la Salud

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

Resumen

Resumen Antecedentes. La migraña es tres veces más frecuente en mujeres que en hombres y está modulada por cambios fisiológicos en los niveles de hormonas ováricas, durante las diferentes etapas de la vida de la mujer. La migraña se inicia con la aparición de la menstruación, mejora durante el segundo y tercer trimestre del embarazo y remite con frecuencia durante la menopausia.

Objetivo. Evaluar la seguridad del tratamiento agudo dela migraña durante el embarazo.

Material y métodos. Se hizo una revisión sistemática dela literatura sobre estudios observacionales analíticos publicados entre enero de 1966 y septiembre de 2007. La búsqueda abarcó las bases de datos de COCHRANE,MEDLINE, EMBASE y LILACS. Los datos se obtuvieron mediante la utilización de PECOT teniendo en cuenta la estrategia de intervención, la calidad metodológica y la presencia de malformaciones congénitas relacionadas con los diferentes medicamentos utilizados para el tratamiento de la migraña aguda.

Resultados. Un total de 389 referencias se obtuvieron delos cuales siete artículos fueron seleccionados por el título y resumen. Cuatro artículos cumplieron con los criterios de inclusión. No se encontraron artículos que describen el riesgo de malformaciones congénitas antes de ser expuestos a acetaminofeno, antiinflamatorios no esteroideos, alcaloides del ergot y/o los opiáceos, sólo se encontraron artículos relacionados con triptanes.

Conclusión. Se encontró datos sobre el riesgo de malformaciones congénitas derivadas de la utilización del sumatriptan en relación con los medicamentos utilizados para el ataque agudo de migraña. La información fue escasa y los estudios tenían limitaciones, lo que hace difícil tener una guía sobre su seguridad durante el embarazo.

Key words: trastornos de jaqueca, embarazo, sumatriptan, anomalías congénitas.

Título traducido de la contribución	Seguridad en el tratamiento de la migraña aguda durante el embarazo: una revisión sistemática
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	18-25
Número de páginas	8
Publicación	Revista de la Facultad de Medicina
Volumen	57
N.º	1
Estado	Publicada - feb. 13 2009

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Medicina reproductiva

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https://revistas.unal.edu.co/index.php/revfacmed/article/view/14458

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title = "Safety in the acute management of migraine during pregnancy: A sistematic Review",

abstract = "Background. Migraine is three times more frequent in females than males and is modulated by changes in ovarian hormones throughout different stages of a female's life; migraine thus begins with the onset of menstruation, improves during the second and third trimester of pregnancy and a remission may sometimes be brought about during menopause. Objetive.Evaluating the safety of acute management of migraine during pregnancy. Materials and methods.A systematic review was made of the literature concerning observational analytical studies. A systematic search and selection was made of all analytical studies (cohort studies and cases and controls studies) regarding the acute management of migraine during pregnancy published between January 1966 and September 2007. The search covered the COCHRANE, MEDLINE, EMBASE and LILACS databases. Data were extracted using the PECOT strategy bearing in mind the intervention strategy, methodological quality and presence of greater or lesser congenital malformations related to the different medicaments used for the acute management of migraine. Results. A total of 389 references were obtained of which 7 articles were selected by title and summary. Four articles complied with the inclusion criteria. No articles were found describing the risk of congenital malformations before being exposed to acetaminophen, antiinflammatory agents non-steroidal, ergot alkaloids and/ or opioids; just articles related to tryptans (specifically sumatryptan) were found. Conclusions. Only data concerning the risk of congenital malformations arising from sumatryptan use was found regarding all the medicaments used for acute migraine attack, this being insufficient as the information was really poor and the studies had limitations, thereby making it difficult to make statements concerning their safety during pregnancy.",

author = "\{Ortiz Salas\}, \{Paola Andrea\} and \{Pinz{\'o}n Fl{\'o}rez\}, \{Carlos Eduardo\} and Guti{\'e}rrez-{\'A}lvarez, \{{\'A}ngela Mar{\'i}a\} and \{Sobrino Mej{\'i}a\}, \{Fidel Ernesto\}",

year = "2009",

month = feb,

day = "13",

language = "English (US)",

volume = "57",

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journal = "Revista de la Facultad de Medicina",

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publisher = "Universidad Nacional de Colombia",

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}

Safety in the acute management of migraine during pregnancy: A sistematic Review. / Ortiz Salas, Paola Andrea; Pinzón Flórez, Carlos Eduardo; Gutiérrez-Álvarez, Ángela María et al.
En: Revista de la Facultad de Medicina, Vol. 57, N.º 1, 13.02.2009, p. 18-25.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Safety in the acute management of migraine during pregnancy: A sistematic Review

AU - Ortiz Salas, Paola Andrea

AU - Pinzón Flórez, Carlos Eduardo

AU - Gutiérrez-Álvarez, Ángela María

AU - Sobrino Mejía, Fidel Ernesto

PY - 2009/2/13

Y1 - 2009/2/13

N2 - Background. Migraine is three times more frequent in females than males and is modulated by changes in ovarian hormones throughout different stages of a female's life; migraine thus begins with the onset of menstruation, improves during the second and third trimester of pregnancy and a remission may sometimes be brought about during menopause. Objetive.Evaluating the safety of acute management of migraine during pregnancy. Materials and methods.A systematic review was made of the literature concerning observational analytical studies. A systematic search and selection was made of all analytical studies (cohort studies and cases and controls studies) regarding the acute management of migraine during pregnancy published between January 1966 and September 2007. The search covered the COCHRANE, MEDLINE, EMBASE and LILACS databases. Data were extracted using the PECOT strategy bearing in mind the intervention strategy, methodological quality and presence of greater or lesser congenital malformations related to the different medicaments used for the acute management of migraine. Results. A total of 389 references were obtained of which 7 articles were selected by title and summary. Four articles complied with the inclusion criteria. No articles were found describing the risk of congenital malformations before being exposed to acetaminophen, antiinflammatory agents non-steroidal, ergot alkaloids and/ or opioids; just articles related to tryptans (specifically sumatryptan) were found. Conclusions. Only data concerning the risk of congenital malformations arising from sumatryptan use was found regarding all the medicaments used for acute migraine attack, this being insufficient as the information was really poor and the studies had limitations, thereby making it difficult to make statements concerning their safety during pregnancy.

AB - Background. Migraine is three times more frequent in females than males and is modulated by changes in ovarian hormones throughout different stages of a female's life; migraine thus begins with the onset of menstruation, improves during the second and third trimester of pregnancy and a remission may sometimes be brought about during menopause. Objetive.Evaluating the safety of acute management of migraine during pregnancy. Materials and methods.A systematic review was made of the literature concerning observational analytical studies. A systematic search and selection was made of all analytical studies (cohort studies and cases and controls studies) regarding the acute management of migraine during pregnancy published between January 1966 and September 2007. The search covered the COCHRANE, MEDLINE, EMBASE and LILACS databases. Data were extracted using the PECOT strategy bearing in mind the intervention strategy, methodological quality and presence of greater or lesser congenital malformations related to the different medicaments used for the acute management of migraine. Results. A total of 389 references were obtained of which 7 articles were selected by title and summary. Four articles complied with the inclusion criteria. No articles were found describing the risk of congenital malformations before being exposed to acetaminophen, antiinflammatory agents non-steroidal, ergot alkaloids and/ or opioids; just articles related to tryptans (specifically sumatryptan) were found. Conclusions. Only data concerning the risk of congenital malformations arising from sumatryptan use was found regarding all the medicaments used for acute migraine attack, this being insufficient as the information was really poor and the studies had limitations, thereby making it difficult to make statements concerning their safety during pregnancy.

M3 - Research Article

SN - 0120-0011

VL - 57

SP - 18

EP - 25

JO - Revista de la Facultad de Medicina

JF - Revista de la Facultad de Medicina

IS - 1

ER -

Safety in the acute management of migraine during pregnancy: A sistematic Review

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