Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

C. P. Lin, I. Adrianto, C. J. Lessard, J. A. Kelly, K. M. Kaufman, J. M. Guthridge, B. I. Freedman, J. M. Anaya, M. E. Alarcón-Riquelme, B. A. Pons-Estel, J. Martin, S. Glenn, A. Adler, S. C. Bae, S. Y. Park, S. Y. Bang, Y. W. Song, S. A. Boackle, E. E. Brown, J. C. EdbergG. S. Alarcón, M. A. Petri, L. A. Criswell, R. Ramsey-Goldman, J. D. Reveille, L. M. Vila, G. S. Gilkeson, D. L. Kamen, J. Ziegler, C. O. Jacob, A. Rasmussen, J. A. James, R. P. Kimberly, J. T. Merrill, T. B. Niewold, R. H. Scofield, A. M. Stevens, B. P. Tsao, T. J. Vyse, C. D. Langefeld, K. L. Moser, J. B. Harley, P. M. Gaffney, C. G. Montgomery

Resultado de la investigación: Contribución a una revistaArtículo

42 Citas (Scopus)

Resumen

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P
Idioma originalInglés estadounidense
Páginas (desde-hasta)232-238
Número de páginas7
PublicaciónGenes and Immunity
DOI
EstadoPublicada - abr 1 2012

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Lin, C. P., Adrianto, I., Lessard, C. J., Kelly, J. A., Kaufman, K. M., Guthridge, J. M., Freedman, B. I., Anaya, J. M., Alarcón-Riquelme, M. E., Pons-Estel, B. A., Martin, J., Glenn, S., Adler, A., Bae, S. C., Park, S. Y., Bang, S. Y., Song, Y. W., Boackle, S. A., Brown, E. E., ... Montgomery, C. G. (2012). Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes and Immunity, 232-238. https://doi.org/10.1038/gene.2011.82