Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

C. P. Lin, I. Adrianto, C. J. Lessard, J. A. Kelly, K. M. Kaufman, J. M. Guthridge, B. I. Freedman, J. M. Anaya, M. E. Alarcón-Riquelme, B. A. Pons-Estel, J. Martin, S. Glenn, A. Adler, S. C. Bae, S. Y. Park, S. Y. Bang, Y. W. Song, S. A. Boackle, E. E. Brown, J. C. Edberg & 24 otros G. S. Alarcón, M. A. Petri, L. A. Criswell, R. Ramsey-Goldman, J. D. Reveille, L. M. Vila, G. S. Gilkeson, D. L. Kamen, J. Ziegler, C. O. Jacob, A. Rasmussen, J. A. James, R. P. Kimberly, J. T. Merrill, T. B. Niewold, R. H. Scofield, A. M. Stevens, B. P. Tsao, T. J. Vyse, C. D. Langefeld, K. L. Moser, J. B. Harley, P. M. Gaffney, C. G. Montgomery

Resultado de la investigación: Contribución a RevistaArtículo

37 Citas (Scopus)

Resumen

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P
Idioma originalEnglish (US)
Páginas (desde-hasta)232-238
Número de páginas7
PublicaciónGenes and Immunity
DOI
EstadoPublished - abr 1 2012

Huella dactilar

Lupus Nephritis
Myosin Heavy Chains
Apolipoproteins
Systemic Lupus Erythematosus
Population
African Americans
Autoantibodies
Autoimmune Diseases
Kidney
Genes

Citar esto

Lin, C. P., Adrianto, I., Lessard, C. J., Kelly, J. A., Kaufman, K. M., Guthridge, J. M., ... Montgomery, C. G. (2012). Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes and Immunity, 232-238. https://doi.org/10.1038/gene.2011.82
Lin, C. P. ; Adrianto, I. ; Lessard, C. J. ; Kelly, J. A. ; Kaufman, K. M. ; Guthridge, J. M. ; Freedman, B. I. ; Anaya, J. M. ; Alarcón-Riquelme, M. E. ; Pons-Estel, B. A. ; Martin, J. ; Glenn, S. ; Adler, A. ; Bae, S. C. ; Park, S. Y. ; Bang, S. Y. ; Song, Y. W. ; Boackle, S. A. ; Brown, E. E. ; Edberg, J. C. ; Alarcón, G. S. ; Petri, M. A. ; Criswell, L. A. ; Ramsey-Goldman, R. ; Reveille, J. D. ; Vila, L. M. ; Gilkeson, G. S. ; Kamen, D. L. ; Ziegler, J. ; Jacob, C. O. ; Rasmussen, A. ; James, J. A. ; Kimberly, R. P. ; Merrill, J. T. ; Niewold, T. B. ; Scofield, R. H. ; Stevens, A. M. ; Tsao, B. P. ; Vyse, T. J. ; Langefeld, C. D. ; Moser, K. L. ; Harley, J. B. ; Gaffney, P. M. ; Montgomery, C. G. / Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. En: Genes and Immunity. 2012 ; pp. 232-238.
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title = "Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis",
abstract = "Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P",
author = "Lin, {C. P.} and I. Adrianto and Lessard, {C. J.} and Kelly, {J. A.} and Kaufman, {K. M.} and Guthridge, {J. M.} and Freedman, {B. I.} and Anaya, {J. M.} and Alarc{\'o}n-Riquelme, {M. E.} and Pons-Estel, {B. A.} and J. Martin and S. Glenn and A. Adler and Bae, {S. C.} and Park, {S. Y.} and Bang, {S. Y.} and Song, {Y. W.} and Boackle, {S. A.} and Brown, {E. E.} and Edberg, {J. C.} and Alarc{\'o}n, {G. S.} and Petri, {M. A.} and Criswell, {L. A.} and R. Ramsey-Goldman and Reveille, {J. D.} and Vila, {L. M.} and Gilkeson, {G. S.} and Kamen, {D. L.} and J. Ziegler and Jacob, {C. O.} and A. Rasmussen and James, {J. A.} and Kimberly, {R. P.} and Merrill, {J. T.} and Niewold, {T. B.} and Scofield, {R. H.} and Stevens, {A. M.} and Tsao, {B. P.} and Vyse, {T. J.} and Langefeld, {C. D.} and Moser, {K. L.} and Harley, {J. B.} and Gaffney, {P. M.} and Montgomery, {C. G.}",
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Lin, CP, Adrianto, I, Lessard, CJ, Kelly, JA, Kaufman, KM, Guthridge, JM, Freedman, BI, Anaya, JM, Alarcón-Riquelme, ME, Pons-Estel, BA, Martin, J, Glenn, S, Adler, A, Bae, SC, Park, SY, Bang, SY, Song, YW, Boackle, SA, Brown, EE, Edberg, JC, Alarcón, GS, Petri, MA, Criswell, LA, Ramsey-Goldman, R, Reveille, JD, Vila, LM, Gilkeson, GS, Kamen, DL, Ziegler, J, Jacob, CO, Rasmussen, A, James, JA, Kimberly, RP, Merrill, JT, Niewold, TB, Scofield, RH, Stevens, AM, Tsao, BP, Vyse, TJ, Langefeld, CD, Moser, KL, Harley, JB, Gaffney, PM & Montgomery, CG 2012, 'Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis', Genes and Immunity, pp. 232-238. https://doi.org/10.1038/gene.2011.82

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. / Lin, C. P.; Adrianto, I.; Lessard, C. J.; Kelly, J. A.; Kaufman, K. M.; Guthridge, J. M.; Freedman, B. I.; Anaya, J. M.; Alarcón-Riquelme, M. E.; Pons-Estel, B. A.; Martin, J.; Glenn, S.; Adler, A.; Bae, S. C.; Park, S. Y.; Bang, S. Y.; Song, Y. W.; Boackle, S. A.; Brown, E. E.; Edberg, J. C.; Alarcón, G. S.; Petri, M. A.; Criswell, L. A.; Ramsey-Goldman, R.; Reveille, J. D.; Vila, L. M.; Gilkeson, G. S.; Kamen, D. L.; Ziegler, J.; Jacob, C. O.; Rasmussen, A.; James, J. A.; Kimberly, R. P.; Merrill, J. T.; Niewold, T. B.; Scofield, R. H.; Stevens, A. M.; Tsao, B. P.; Vyse, T. J.; Langefeld, C. D.; Moser, K. L.; Harley, J. B.; Gaffney, P. M.; Montgomery, C. G.

En: Genes and Immunity, 01.04.2012, p. 232-238.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

AU - Lin, C. P.

AU - Adrianto, I.

AU - Lessard, C. J.

AU - Kelly, J. A.

AU - Kaufman, K. M.

AU - Guthridge, J. M.

AU - Freedman, B. I.

AU - Anaya, J. M.

AU - Alarcón-Riquelme, M. E.

AU - Pons-Estel, B. A.

AU - Martin, J.

AU - Glenn, S.

AU - Adler, A.

AU - Bae, S. C.

AU - Park, S. Y.

AU - Bang, S. Y.

AU - Song, Y. W.

AU - Boackle, S. A.

AU - Brown, E. E.

AU - Edberg, J. C.

AU - Alarcón, G. S.

AU - Petri, M. A.

AU - Criswell, L. A.

AU - Ramsey-Goldman, R.

AU - Reveille, J. D.

AU - Vila, L. M.

AU - Gilkeson, G. S.

AU - Kamen, D. L.

AU - Ziegler, J.

AU - Jacob, C. O.

AU - Rasmussen, A.

AU - James, J. A.

AU - Kimberly, R. P.

AU - Merrill, J. T.

AU - Niewold, T. B.

AU - Scofield, R. H.

AU - Stevens, A. M.

AU - Tsao, B. P.

AU - Vyse, T. J.

AU - Langefeld, C. D.

AU - Moser, K. L.

AU - Harley, J. B.

AU - Gaffney, P. M.

AU - Montgomery, C. G.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P

AB - Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P

U2 - 10.1038/gene.2011.82

DO - 10.1038/gene.2011.82

M3 - Article

SP - 232

EP - 238

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

ER -

Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM y otros. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes and Immunity. 2012 abr 1;232-238. https://doi.org/10.1038/gene.2011.82