RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions

Luz Helena Patino, Juan David Ramírez

Resultado de la investigación: Contribución a RevistaRevisión Literaria

7 Citas (Scopus)

Resumen

© 2017 Elsevier B.V.The kinetoplastids include a large number of parasites responsible for serious diseases in humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several regions of the world. These parasites are characterized by digenetic life cycles that undergo morphological and genetic changes that allow them to adapt to different microenvironments on their vertebrates and invertebrates hosts. Recent advances in ´omics´ technology, specifically transcriptomics have allowed to reveal aspects associated with such molecular changes. So far, different techniques have been used to evaluate the gene expression profile during the various stages of the life cycle of these parasites and during the host-parasite interactions. However, some of them have serious drawbacks that limit the precise study and full understanding of their transcriptomes. Therefore, recently has been implemented the latest technology (RNA-seq), which overcomes the drawbacks of traditional methods. In this review, studies that so far have used RNA-seq are presented and allowed to expand our knowledge regarding the biology of these parasites and their interactions with their hosts.
Idioma originalEnglish (US)
Páginas (desde-hasta)273-282
Número de páginas10
PublicaciónInfection, Genetics and Evolution
DOI
EstadoPublished - abr 1 2017

Huella dactilar

host-pathogen interaction
Host-Pathogen Interactions
host-pathogen relationships
RNA
parasite
Parasites
parasites
Biological Sciences
Life Cycle Stages
Transcriptome
life cycle
Technology
host-parasite interaction
diseases and disorders (animals and humans)
Host-Parasite Interactions
Trypanosoma brucei
Trypanosoma brucei brucei
Leishmania
host-parasite relationships
Invertebrates

Citar esto

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RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions. / Patino, Luz Helena; Ramírez, Juan David.

En: Infection, Genetics and Evolution, 01.04.2017, p. 273-282.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions

AU - Patino, Luz Helena

AU - Ramírez, Juan David

PY - 2017/4/1

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N2 - © 2017 Elsevier B.V.The kinetoplastids include a large number of parasites responsible for serious diseases in humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several regions of the world. These parasites are characterized by digenetic life cycles that undergo morphological and genetic changes that allow them to adapt to different microenvironments on their vertebrates and invertebrates hosts. Recent advances in ´omics´ technology, specifically transcriptomics have allowed to reveal aspects associated with such molecular changes. So far, different techniques have been used to evaluate the gene expression profile during the various stages of the life cycle of these parasites and during the host-parasite interactions. However, some of them have serious drawbacks that limit the precise study and full understanding of their transcriptomes. Therefore, recently has been implemented the latest technology (RNA-seq), which overcomes the drawbacks of traditional methods. In this review, studies that so far have used RNA-seq are presented and allowed to expand our knowledge regarding the biology of these parasites and their interactions with their hosts.

AB - © 2017 Elsevier B.V.The kinetoplastids include a large number of parasites responsible for serious diseases in humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several regions of the world. These parasites are characterized by digenetic life cycles that undergo morphological and genetic changes that allow them to adapt to different microenvironments on their vertebrates and invertebrates hosts. Recent advances in ´omics´ technology, specifically transcriptomics have allowed to reveal aspects associated with such molecular changes. So far, different techniques have been used to evaluate the gene expression profile during the various stages of the life cycle of these parasites and during the host-parasite interactions. However, some of them have serious drawbacks that limit the precise study and full understanding of their transcriptomes. Therefore, recently has been implemented the latest technology (RNA-seq), which overcomes the drawbacks of traditional methods. In this review, studies that so far have used RNA-seq are presented and allowed to expand our knowledge regarding the biology of these parasites and their interactions with their hosts.

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DO - 10.1016/j.meegid.2017.02.003

M3 - Literature review

SP - 273

EP - 282

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

SN - 1567-1348

ER -