TY - JOUR
T1 - Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease
T2 - data from the AIDA network registry
AU - Vitale, Antonio
AU - Caggiano, Valeria
AU - Sbalchiero, Jessica
AU - Gavioli, Francesco
AU - Lopalco, Giuseppe
AU - Ragab, Gaafar
AU - Guerriero, Silvana
AU - Almaglouth, Ibrahim
AU - Tufan, Abdurrahman
AU - Giacomelli, Roberto
AU - Direskeneli, Haner
AU - Ruscitti, Piero
AU - Hatemi, Gülen
AU - Carubbi, Francesco
AU - Batu, Ezgi Deniz
AU - Ozen, Seza
AU - Sota, Jurgen
AU - Giardini, Henrique Ayres Mayrink
AU - Frassi, Micol
AU - Sfikakis, Petros P.
AU - Morrone, Maria
AU - Gatti, Federica
AU - Maher, Amina
AU - Mahmoud, Ayman Abdel Monem Ahmed
AU - Dammacco, Rosanna
AU - Kucuk, Hamit
AU - Kardas, Riza Can
AU - Cakir, Ibrahim Yahya
AU - Corcia, Letizia Pia di
AU - Öner, Fatma Alibaz
AU - Sevik, Gizem
AU - Gentile, Martina
AU - Karakoc, Alican
AU - Alunno, Alessia
AU - Emreol, Hulya Ercan
AU - Crisafulli, Francesca
AU - Tektonidou, Maria
AU - Ciccia, Francesco
AU - Thabet, Maissa
AU - Bugatti, Serena
AU - Milanesi, Alessandra
AU - Chimenti, Maria Sole
AU - Monosi, Benedetta
AU - Piga, Matteo
AU - Floris, Alberto
AU - Hinojosa-Azaola, Andrea
AU - Guaracha-Basañez, Guillermo Arturo
AU - Chighizola, Cecilia Beatrice
AU - Hernández-Rodríguez, José
AU - Cattalini, Marco
AU - Govoni, Marcello
AU - Viapiana, Ombretta
AU - Civino, Adele
AU - Opris-Belinski, Daniela
AU - Gaggiano, Carla
AU - Talarico, Rosaria
AU - Giardina, Annarita
AU - Emmi, Giacomo
AU - Puttini, Piercarlo Sarzi
AU - Maggio, Maria Cristina
AU - Parronchi, Paola
AU - Portincasa, Piero
AU - de-la-Torre, Alejandra
AU - Cardona-López, Juanita
AU - Gentileschi, Stefano
AU - Mauro, Angela
AU - Sebastiani, Gian Domenico
AU - Gicchino, Maria Francesca
AU - Şahin, Ali
AU - Rigante, Donato
AU - Bilgin, Emre
AU - Del Giudice, Emanuela
AU - Breda, Luciana
AU - De Paulis, Amato
AU - Lo Gullo, Alberto
AU - Erten, Şükran
AU - Tharwat, Samar
AU - Fotis, Lampros
AU - Armin, Maier
AU - Insalaco, Antonella
AU - Karamanakos, Anastasios
AU - Conforti, Alessandro
AU - Gündüz, Özgül Soysal
AU - Moshrif, Abdelhfeez
AU - Li Gobbi, Francesca
AU - Costi, Stefania
AU - Bartoloni, Elena
AU - Barone, Patrizia
AU - Guiducci, Serena
AU - González-García, Andrés
AU - Rodriguez, Inés Hernanz
AU - Conti, Giovanni
AU - Iagnocco, Annamaria
AU - Önen, Fatos
AU - Al-Mayouf, Sulaiman M.
AU - Hatemi, Ali İbrahim
AU - Balistreri, Alberto
AU - Fabiani, Claudia
AU - Cantarini, Luca
N1 - Publisher Copyright:
Copyright © 2026 Vitale, Caggiano, Sbalchiero, Gavioli, Lopalco, Ragab, Guerriero, Almaglouth, Tufan, Giacomelli, Direskeneli, Ruscitti, Hatemi, Carubbi, Batu, Ozen, Sota, Giardini, Frassi, Sfikakis, Morrone, Gatti, Maher, Mahmoud, Dammacco, Kucuk, Kardas, Cakir, Corcia, Öner, Sevik, Gentile, Karakoc, Alunno, Emreol, Crisafulli, Tektonidou, Ciccia, Thabet, Bugatti, Milanesi, Chimenti, Monosi, Piga, Floris, Hinojosa-Azaola, Guaracha-Basañez, Chighizola, Hernández-Rodríguez, Cattalini, Govoni, Viapiana, Civino, Opris-Belinski, Gaggiano, Talarico, Giardina, Emmi, Puttini, Maggio, Parronchi, Portincasa, de-la-Torre, Cardona-López, Gentileschi, Mauro, Sebastiani, Gicchino, Şahin, Rigante, Bilgin, Del Giudice, Breda, De Paulis, Lo Gullo, Erten, Tharwat, Fotis, Armin, Insalaco, Karamanakos, Conforti, Gündüz, Moshrif, Li Gobbi, Costi, Bartoloni, Barone, Guiducci, González-García, Rodriguez, Conti, Iagnocco, Önen, Al-Mayouf, Hatemi, Balistreri, Fabiani and Cantarini.
PY - 2026/5/13
Y1 - 2026/5/13
N2 - Objective – Behçet’s disease (BD) may initially manifest solely with mucocutaneous involvement. This study aimed to identify demographic and clinical factors associated with subsequent intestinal involvement in patients presenting exclusively with mucocutaneous manifestations during early disease stages. Methods – Data were obtained from the International AutoInflammatory Disease Alliance Network registry dedicated to BD; a Bayesian statistical approach was employed to address the limited sample size resulting from subgroup stratifications. Results – In total, 328 BD patients with exclusively mucocutaneous onset were enrolled; of these, 46 (14%) developed intestinal involvement over time. The risk of ocular involvement was higher among patients with intestinal manifestations (OR: 3.02, 95% CrI: 1.24–6.08; posterior probability: 99.3%). Minor aphthous ulcers without major aphthosis were protective towards intestinal involvement (OR: 0.47, 95% CrI: 0.22–0.98; posterior probability: 97.98%). Conversely, major aphthous ulcers increased the risk (OR: 3.25, 95% CrI: 1.50–7.02; posterior probability: 99.7%), along with the combination of oral major aphthosis with: i) genital aphthosis (OR = 2.77, 95%CrI: 1.14-6.58; posterior probability: 98.45%); ii) pseudofolliculitis (OR = 3.18, 95%CrI: 1.15-8.33; posterior probability: 98.72%); iii) genital aphthosis plus pseudofolliculitis (OR = 5.22, 95%CrI: 1.71-16.35; posterior probability of 99.77%). Pseudofolliculitis plus cutaneous manifestations other than erythema nodosum were protective against intestinal involvement (OR = 0.01, 95%CrI: 0.0-0.98; posterior probability: 97.55%). Conclusion – Major aphthosis was the strongest factor associated with intestinal involvement in BD patients initially presenting with mucocutaneous symptoms only. In such patients, intestinal involvement correlated with increased risk of ocular inflammation.
AB - Objective – Behçet’s disease (BD) may initially manifest solely with mucocutaneous involvement. This study aimed to identify demographic and clinical factors associated with subsequent intestinal involvement in patients presenting exclusively with mucocutaneous manifestations during early disease stages. Methods – Data were obtained from the International AutoInflammatory Disease Alliance Network registry dedicated to BD; a Bayesian statistical approach was employed to address the limited sample size resulting from subgroup stratifications. Results – In total, 328 BD patients with exclusively mucocutaneous onset were enrolled; of these, 46 (14%) developed intestinal involvement over time. The risk of ocular involvement was higher among patients with intestinal manifestations (OR: 3.02, 95% CrI: 1.24–6.08; posterior probability: 99.3%). Minor aphthous ulcers without major aphthosis were protective towards intestinal involvement (OR: 0.47, 95% CrI: 0.22–0.98; posterior probability: 97.98%). Conversely, major aphthous ulcers increased the risk (OR: 3.25, 95% CrI: 1.50–7.02; posterior probability: 99.7%), along with the combination of oral major aphthosis with: i) genital aphthosis (OR = 2.77, 95%CrI: 1.14-6.58; posterior probability: 98.45%); ii) pseudofolliculitis (OR = 3.18, 95%CrI: 1.15-8.33; posterior probability: 98.72%); iii) genital aphthosis plus pseudofolliculitis (OR = 5.22, 95%CrI: 1.71-16.35; posterior probability of 99.77%). Pseudofolliculitis plus cutaneous manifestations other than erythema nodosum were protective against intestinal involvement (OR = 0.01, 95%CrI: 0.0-0.98; posterior probability: 97.55%). Conclusion – Major aphthosis was the strongest factor associated with intestinal involvement in BD patients initially presenting with mucocutaneous symptoms only. In such patients, intestinal involvement correlated with increased risk of ocular inflammation.
UR - https://www.scopus.com/pages/publications/105043245054
UR - https://www.scopus.com/pages/publications/105043245054#tab=citedBy
U2 - 10.3389/fimmu.2026.1778171
DO - 10.3389/fimmu.2026.1778171
M3 - Research Article
C2 - 42212137
AN - SCOPUS:105043245054
SN - 1664-3224
VL - 17
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1778171
ER -