Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis

Adriana Rojas-Villarraga, Oscar Danilo Ortega-Hernandez, Luis F. Gomez, Aryce L. Pardo, Silvia López-Guzmán, Camila Arango-Ferreira, Maria Eugenia Hincapie, Juan F. Betancur, Ricardo Pineda-Tamayo, Francisco J. Diaz, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

32 Citas (Scopus)

Resumen

Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods: A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV 1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age. Results: Rheumatoid factor seropositivity was significantly associated with endothelial dysfunction (adjusted odds ratio, AOR = 3.0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque. No association of extra-articular manifestations, anticyclic citrullinated peptide (anti-CCP3) antibodies, and tumor necrosis factor -308 polymorphism with CVD was found. Conclusions: Our results reveal the presence of RA-related risk factors for CVD which act independently of traditional risk factors. These factors can be used by clinicians to predict CVD in RA patients, and this data should assist in the development of public health policies in our population for the improvement of patient outcomes. © 2008 Elsevier Inc. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)71-82
Número de páginas12
PublicaciónSeminars in Arthritis and Rheumatism
DOI
EstadoPublished - oct 1 2008

Huella dactilar

Rheumatoid Arthritis
Atherosclerosis
Cardiovascular Diseases
Vasodilation
HLA-DRB1 Chains
Carotid Intima-Media Thickness
Rheumatoid Factor
Genetic Association Studies
Atherosclerotic Plaques
Public Policy
Health Policy
Genetic Markers
Epitopes
Anti-Idiotypic Antibodies
Ultrasonography
Public Health
Arteries
Tumor Necrosis Factor-alpha
Joints
Alleles

Citar esto

Rojas-Villarraga, Adriana ; Ortega-Hernandez, Oscar Danilo ; Gomez, Luis F. ; Pardo, Aryce L. ; López-Guzmán, Silvia ; Arango-Ferreira, Camila ; Hincapie, Maria Eugenia ; Betancur, Juan F. ; Pineda-Tamayo, Ricardo ; Diaz, Francisco J. ; Anaya, Juan Manuel. / Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis. En: Seminars in Arthritis and Rheumatism. 2008 ; pp. 71-82.
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title = "Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis",
abstract = "Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods: A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV 1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age. Results: Rheumatoid factor seropositivity was significantly associated with endothelial dysfunction (adjusted odds ratio, AOR = 3.0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque. No association of extra-articular manifestations, anticyclic citrullinated peptide (anti-CCP3) antibodies, and tumor necrosis factor -308 polymorphism with CVD was found. Conclusions: Our results reveal the presence of RA-related risk factors for CVD which act independently of traditional risk factors. These factors can be used by clinicians to predict CVD in RA patients, and this data should assist in the development of public health policies in our population for the improvement of patient outcomes. {\circledC} 2008 Elsevier Inc. All rights reserved.",
author = "Adriana Rojas-Villarraga and Ortega-Hernandez, {Oscar Danilo} and Gomez, {Luis F.} and Pardo, {Aryce L.} and Silvia L{\'o}pez-Guzm{\'a}n and Camila Arango-Ferreira and Hincapie, {Maria Eugenia} and Betancur, {Juan F.} and Ricardo Pineda-Tamayo and Diaz, {Francisco J.} and Anaya, {Juan Manuel}",
year = "2008",
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doi = "10.1016/j.semarthrit.2008.01.019",
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pages = "71--82",
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publisher = "W.B. Saunders Ltd",

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Rojas-Villarraga, A, Ortega-Hernandez, OD, Gomez, LF, Pardo, AL, López-Guzmán, S, Arango-Ferreira, C, Hincapie, ME, Betancur, JF, Pineda-Tamayo, R, Diaz, FJ & Anaya, JM 2008, 'Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis', Seminars in Arthritis and Rheumatism, pp. 71-82. https://doi.org/10.1016/j.semarthrit.2008.01.019

Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis. / Rojas-Villarraga, Adriana; Ortega-Hernandez, Oscar Danilo; Gomez, Luis F.; Pardo, Aryce L.; López-Guzmán, Silvia; Arango-Ferreira, Camila; Hincapie, Maria Eugenia; Betancur, Juan F.; Pineda-Tamayo, Ricardo; Diaz, Francisco J.; Anaya, Juan Manuel.

En: Seminars in Arthritis and Rheumatism, 01.10.2008, p. 71-82.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Risk Factors Associated with Different Stages of Atherosclerosis in Colombian Patients with Rheumatoid Arthritis

AU - Rojas-Villarraga, Adriana

AU - Ortega-Hernandez, Oscar Danilo

AU - Gomez, Luis F.

AU - Pardo, Aryce L.

AU - López-Guzmán, Silvia

AU - Arango-Ferreira, Camila

AU - Hincapie, Maria Eugenia

AU - Betancur, Juan F.

AU - Pineda-Tamayo, Ricardo

AU - Diaz, Francisco J.

AU - Anaya, Juan Manuel

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods: A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV 1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age. Results: Rheumatoid factor seropositivity was significantly associated with endothelial dysfunction (adjusted odds ratio, AOR = 3.0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque. No association of extra-articular manifestations, anticyclic citrullinated peptide (anti-CCP3) antibodies, and tumor necrosis factor -308 polymorphism with CVD was found. Conclusions: Our results reveal the presence of RA-related risk factors for CVD which act independently of traditional risk factors. These factors can be used by clinicians to predict CVD in RA patients, and this data should assist in the development of public health policies in our population for the improvement of patient outcomes. © 2008 Elsevier Inc. All rights reserved.

AB - Objectives: Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD). Since atherosclerosis development is a gradual process of damage inside the artery wall, and the phenotype-genotype correlation of complex diseases may vary depending on ethnicity, we sought to investigate the influence of clinical features, routine inflammatory markers, and the genetic component of RA on different stages of atherosclerosis in northwestern Colombian patients with RA. Methods: A group of 140 patients with RA were enrolled in this study. All patients underwent a noninvasive evaluation of endothelial function by flow-mediated vasodilation (FMV) and an assessment of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography. The patients were classified into 3 categories: endothelial dysfunction (FMV 1.30 mm). The risk of being in each category was assessed by investigating traditional and nontraditional cardiovascular risk factors. For each stage of atherosclerosis development, we searched for nontraditional risk factors that were significantly associated with the stage after adjusting for traditional risk factors and current age. Results: Rheumatoid factor seropositivity was significantly associated with endothelial dysfunction (adjusted odds ratio, AOR = 3.0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque. No association of extra-articular manifestations, anticyclic citrullinated peptide (anti-CCP3) antibodies, and tumor necrosis factor -308 polymorphism with CVD was found. Conclusions: Our results reveal the presence of RA-related risk factors for CVD which act independently of traditional risk factors. These factors can be used by clinicians to predict CVD in RA patients, and this data should assist in the development of public health policies in our population for the improvement of patient outcomes. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.semarthrit.2008.01.019

DO - 10.1016/j.semarthrit.2008.01.019

M3 - Article

C2 - 18395773

SP - 71

EP - 82

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

SN - 0049-0172

ER -