Reticulocytes: Plasmodium vivax target cells

Darwin A. Moreno-Pérez, Jhenniffer A. Ruíz, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaRevisión Literaria

9 Citas (Scopus)

Resumen

Reticulocytes represent the main invasion target for Plasmodium vivax, the second most prevalent parasite species around the world causing malaria in humans. In spite of these cells' importance in research into malaria, biological knowledge related to the nature of the host has been limited, given the technical difficulties present in working with them in the laboratory. Poor reticulocyte recovery from total blood, by different techniques, has hampered continuous in vitro P. vivax cultures being developed, thereby delaying basic investigation in this parasite species. Intense research during the last few years has led to advances being made in developing methodologies orientated towards obtaining enriched reticulocytes from differing sources, thereby providing invaluable information for developing new strategies aimed at preventing infection caused by malaria. This review describes the most recent studies related to obtaining reticulocytes and discusses approaches which could contribute towards knowledge regarding molecular interactions between target cell proteins and their main infective agent, P. vivax. © 2013 Société Française des Microscopies and Société de Biologie Cellulaire de France.
Idioma originalEnglish (US)
Páginas (desde-hasta)251-260
Número de páginas10
PublicaciónBiology of the Cell
DOI
EstadoPublished - jun 1 2013

Huella dactilar

Plasmodium vivax
Reticulocytes
Malaria
Parasites
Research
France
Microscopy
Infection
Proteins

Citar esto

Moreno-Pérez, Darwin A. ; Ruíz, Jhenniffer A. ; Patarroyo, Manuel A. / Reticulocytes: Plasmodium vivax target cells. En: Biology of the Cell. 2013 ; pp. 251-260.
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abstract = "Reticulocytes represent the main invasion target for Plasmodium vivax, the second most prevalent parasite species around the world causing malaria in humans. In spite of these cells' importance in research into malaria, biological knowledge related to the nature of the host has been limited, given the technical difficulties present in working with them in the laboratory. Poor reticulocyte recovery from total blood, by different techniques, has hampered continuous in vitro P. vivax cultures being developed, thereby delaying basic investigation in this parasite species. Intense research during the last few years has led to advances being made in developing methodologies orientated towards obtaining enriched reticulocytes from differing sources, thereby providing invaluable information for developing new strategies aimed at preventing infection caused by malaria. This review describes the most recent studies related to obtaining reticulocytes and discusses approaches which could contribute towards knowledge regarding molecular interactions between target cell proteins and their main infective agent, P. vivax. {\circledC} 2013 Soci{\'e}t{\'e} Fran{\cc}aise des Microscopies and Soci{\'e}t{\'e} de Biologie Cellulaire de France.",
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Reticulocytes: Plasmodium vivax target cells. / Moreno-Pérez, Darwin A.; Ruíz, Jhenniffer A.; Patarroyo, Manuel A.

En: Biology of the Cell, 01.06.2013, p. 251-260.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Reticulocytes: Plasmodium vivax target cells

AU - Moreno-Pérez, Darwin A.

AU - Ruíz, Jhenniffer A.

AU - Patarroyo, Manuel A.

PY - 2013/6/1

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N2 - Reticulocytes represent the main invasion target for Plasmodium vivax, the second most prevalent parasite species around the world causing malaria in humans. In spite of these cells' importance in research into malaria, biological knowledge related to the nature of the host has been limited, given the technical difficulties present in working with them in the laboratory. Poor reticulocyte recovery from total blood, by different techniques, has hampered continuous in vitro P. vivax cultures being developed, thereby delaying basic investigation in this parasite species. Intense research during the last few years has led to advances being made in developing methodologies orientated towards obtaining enriched reticulocytes from differing sources, thereby providing invaluable information for developing new strategies aimed at preventing infection caused by malaria. This review describes the most recent studies related to obtaining reticulocytes and discusses approaches which could contribute towards knowledge regarding molecular interactions between target cell proteins and their main infective agent, P. vivax. © 2013 Société Française des Microscopies and Société de Biologie Cellulaire de France.

AB - Reticulocytes represent the main invasion target for Plasmodium vivax, the second most prevalent parasite species around the world causing malaria in humans. In spite of these cells' importance in research into malaria, biological knowledge related to the nature of the host has been limited, given the technical difficulties present in working with them in the laboratory. Poor reticulocyte recovery from total blood, by different techniques, has hampered continuous in vitro P. vivax cultures being developed, thereby delaying basic investigation in this parasite species. Intense research during the last few years has led to advances being made in developing methodologies orientated towards obtaining enriched reticulocytes from differing sources, thereby providing invaluable information for developing new strategies aimed at preventing infection caused by malaria. This review describes the most recent studies related to obtaining reticulocytes and discusses approaches which could contribute towards knowledge regarding molecular interactions between target cell proteins and their main infective agent, P. vivax. © 2013 Société Française des Microscopies and Société de Biologie Cellulaire de France.

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JO - Biology of the Cell

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