Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase

Medicina y ciencias biológicas

• Cryptococcus gattii 100%
• Lanosterol 95%
• Azoles 77%
• Fluconazole 46%
• Voriconazole 38%
• Cryptococcus neoformans 38%
• Mycoses 20%
• Cryptococcal Meningitis 14%
• Amino Acids 14%
• Cryptococcosis 13%
• Itraconazole 12%
• Mutation 11%
• Immunocompromised Host 10%
• Treatment Failure 9%
• Acquired Immunodeficiency Syndrome 8%
• Phenotype 6%
• Enzymes 5%
• In Vitro Techniques 4%
• Pharmaceutical Preparations 4%
• Genes 4%
• Therapeutics 1%

Agricultura y biología

• Cryptococcus gattii 95%
• lanosterol 86%
• azoles 83%
• fluconazole 55%
• Cryptococcus neoformans 38%
• resistance mechanisms 20%
• amino acid composition 19%
• cryptococcosis 15%
• itraconazole 14%
• mutation 13%
• mycoses 13%
• meningitis 13%
• prognosis 12%
• therapeutics 7%
• death 7%
• drugs 6%
• phenotype 6%
• infection 5%
• enzymes 4%
• testing 3%
• genes 3%

Ciencias ambientales y de la tierra

• substitution 54%
• substrate 41%
• mutation 40%
• amino acid 37%
• meningitis 31%
• acquired immune deficiency syndrome 26%
• phenotype 22%
• therapy 21%
• infection 18%
• participation 17%
• drug 16%
• enzyme 16%
• gene 15%
• world 11%