Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study

Z. Hawi, T.D.R. Cummins, J. Tong, M. Arcos-Burgos, Q. Zhao, N. Matthews, D.P. Newman, B. Johnson, A. Vance, H.S. Heussler, F. Levy, S. Easteal, N.R. Wray, E. Kenny, D. Morris, L. Kent, M. Gill, M.A. Bellgrove

Resultado de la investigación: Contribución a RevistaArtículo

7 Citas (Scopus)

Resumen

Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (
Idioma originalEnglish (US)
Páginas (desde-hasta)580-584
Número de páginas5
PublicaciónMolecular Psychiatry
Volumen22
N.º4
DOI
EstadoPublished - 2017

Huella dactilar

Brain-Derived Neurotrophic Factor
Attention Deficit Disorder with Hyperactivity
DNA
Genes
Genome-Wide Association Study
Psychiatry

Citar esto

Hawi, Z. ; Cummins, T.D.R. ; Tong, J. ; Arcos-Burgos, M. ; Zhao, Q. ; Matthews, N. ; Newman, D.P. ; Johnson, B. ; Vance, A. ; Heussler, H.S. ; Levy, F. ; Easteal, S. ; Wray, N.R. ; Kenny, E. ; Morris, D. ; Kent, L. ; Gill, M. ; Bellgrove, M.A. / Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study. En: Molecular Psychiatry. 2017 ; Vol. 22, N.º 4. pp. 580-584.
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abstract = "Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (",
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Hawi, Z, Cummins, TDR, Tong, J, Arcos-Burgos, M, Zhao, Q, Matthews, N, Newman, DP, Johnson, B, Vance, A, Heussler, HS, Levy, F, Easteal, S, Wray, NR, Kenny, E, Morris, D, Kent, L, Gill, M & Bellgrove, MA 2017, 'Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study', Molecular Psychiatry, vol. 22, n.º 4, pp. 580-584. https://doi.org/10.1038/mp.2016.117

Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study. / Hawi, Z.; Cummins, T.D.R.; Tong, J.; Arcos-Burgos, M.; Zhao, Q.; Matthews, N.; Newman, D.P.; Johnson, B.; Vance, A.; Heussler, H.S.; Levy, F.; Easteal, S.; Wray, N.R.; Kenny, E.; Morris, D.; Kent, L.; Gill, M.; Bellgrove, M.A.

En: Molecular Psychiatry, Vol. 22, N.º 4, 2017, p. 580-584.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study

AU - Hawi, Z.

AU - Cummins, T.D.R.

AU - Tong, J.

AU - Arcos-Burgos, M.

AU - Zhao, Q.

AU - Matthews, N.

AU - Newman, D.P.

AU - Johnson, B.

AU - Vance, A.

AU - Heussler, H.S.

AU - Levy, F.

AU - Easteal, S.

AU - Wray, N.R.

AU - Kenny, E.

AU - Morris, D.

AU - Kent, L.

AU - Gill, M.

AU - Bellgrove, M.A.

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AB - Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (

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