Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties

Bluma L. Faintuch, Erica A. Oliveira, Julian E. Munõz, Luiz R. Travassos, Carlos P. Taborda

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. The peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. The radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, with marked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM.

Idioma originalInglés estadounidense
Páginas (desde-hasta)544-548
Número de páginas5
PublicaciónMedical Mycology
Volumen52
N.º5
DOI
EstadoPublicada - jul 2014
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Enfermedades infecciosas

Huella Profundice en los temas de investigación de 'Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties'. En conjunto forman una huella única.

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