Pulmonary embolism secondary to inappropriate use of oral contraceptive therapy

A case report

Camilo Alberto Domínguez-Domínguez, Mauricio Orlando Nava-Mesa, Carlos Alberto Calderón-Ospina

Resultado de la investigación: Contribución a RevistaArtículo

Resumen

Forty-one year old female admitted to the hospital because of symptoms and signs suggestive of pulmonary thromboembolism which was confirmed by CT angiography. There was no history of prior thromboembolic events, smoking, venous stasis or vascular lesion (negative lupus anticoagulant and anticardiolipins). The only documented hypercoagulability factor was the use of an oral contraceptive containing drospirenone and ethinylestradiol for the last year. The patient was treated with anticoagulants such as enoxaparin and she recovered without sequelae; she is currently under treatment with warfarin as an outpatient. It is known that the use of combined oral contraceptives in patients over 35 years old requires caution, largely due to higher risk of thromboembolic events associated with increased hepatic synthesis of several coagulation factors. Therefore, this case represents a potentially fatal and preventable severe adverse reaction.

Idioma originalEspañol
Páginas (desde-hasta)162-170
Número de páginas9
PublicaciónRevista Cubana de Farmacia
Volumen50
N.º1
EstadoPublished - ene 1 2016

Huella dactilar

Contraceptives, Oral, Combined
Enoxaparin
Lupus Coagulation Inhibitor
Ethinyl Estradiol
Blood Coagulation Factors
Angiography
Warfarin
Oral Contraceptives
Pulmonary Embolism
Anticoagulants
Thrombophilia
Signs and Symptoms
Blood Vessels
Outpatients
Smoking
Liver
Therapeutics
drospirenone
Computed Tomography Angiography

All Science Journal Classification (ASJC) codes

  • Pharmacy
  • Pharmacology
  • Pharmaceutical Science

Citar esto

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abstract = "Forty-one year old female admitted to the hospital because of symptoms and signs suggestive of pulmonary thromboembolism which was confirmed by CT angiography. There was no history of prior thromboembolic events, smoking, venous stasis or vascular lesion (negative lupus anticoagulant and anticardiolipins). The only documented hypercoagulability factor was the use of an oral contraceptive containing drospirenone and ethinylestradiol for the last year. The patient was treated with anticoagulants such as enoxaparin and she recovered without sequelae; she is currently under treatment with warfarin as an outpatient. It is known that the use of combined oral contraceptives in patients over 35 years old requires caution, largely due to higher risk of thromboembolic events associated with increased hepatic synthesis of several coagulation factors. Therefore, this case represents a potentially fatal and preventable severe adverse reaction.",
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Pulmonary embolism secondary to inappropriate use of oral contraceptive therapy : A case report. / Domínguez-Domínguez, Camilo Alberto; Nava-Mesa, Mauricio Orlando; Calderón-Ospina, Carlos Alberto.

En: Revista Cubana de Farmacia, Vol. 50, N.º 1, 01.01.2016, p. 162-170.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

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T2 - A case report

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AU - Calderón-Ospina, Carlos Alberto

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AB - Forty-one year old female admitted to the hospital because of symptoms and signs suggestive of pulmonary thromboembolism which was confirmed by CT angiography. There was no history of prior thromboembolic events, smoking, venous stasis or vascular lesion (negative lupus anticoagulant and anticardiolipins). The only documented hypercoagulability factor was the use of an oral contraceptive containing drospirenone and ethinylestradiol for the last year. The patient was treated with anticoagulants such as enoxaparin and she recovered without sequelae; she is currently under treatment with warfarin as an outpatient. It is known that the use of combined oral contraceptives in patients over 35 years old requires caution, largely due to higher risk of thromboembolic events associated with increased hepatic synthesis of several coagulation factors. Therefore, this case represents a potentially fatal and preventable severe adverse reaction.

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