Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease

Ángela María Ruiz, Jaime Enrique Ruiz, Andrés Velásquez Gavilanes, Tiina Eriksson, Matti Lehtinen, Gonzalo Pérez, Heather L. Sings, Margaret K. James, Richard M. Haupt

Resultado de la investigación: Contribución a RevistaArtículo

6 Citas (Scopus)

Resumen

Background We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95% CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. © 2012 The Author.
Idioma originalEnglish (US)
Páginas (desde-hasta)1887-1896
Número de páginas10
PublicaciónJournal of Infectious Diseases
DOI
EstadoPublished - dic 15 2012

Huella dactilar

Menarche
Coitus
Human papillomavirus 11
Human papillomavirus 6
Odds Ratio
Confidence Intervals
Cervical Intraepithelial Neoplasia
Primary Prevention
Vaccination
Vaccines
Placebos

Citar esto

Ruiz, Á. M., Ruiz, J. E., Gavilanes, A. V., Eriksson, T., Lehtinen, M., Pérez, G., ... Haupt, R. M. (2012). Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. Journal of Infectious Diseases, 1887-1896. https://doi.org/10.1093/infdis/jis612
Ruiz, Ángela María ; Ruiz, Jaime Enrique ; Gavilanes, Andrés Velásquez ; Eriksson, Tiina ; Lehtinen, Matti ; Pérez, Gonzalo ; Sings, Heather L. ; James, Margaret K. ; Haupt, Richard M. / Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. En: Journal of Infectious Diseases. 2012 ; pp. 1887-1896.
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abstract = "Background We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95{\%} confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95{\%} CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. {\circledC} 2012 The Author.",
author = "Ruiz, {{\'A}ngela Mar{\'i}a} and Ruiz, {Jaime Enrique} and Gavilanes, {Andr{\'e}s Vel{\'a}squez} and Tiina Eriksson and Matti Lehtinen and Gonzalo P{\'e}rez and Sings, {Heather L.} and James, {Margaret K.} and Haupt, {Richard M.}",
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Ruiz, ÁM, Ruiz, JE, Gavilanes, AV, Eriksson, T, Lehtinen, M, Pérez, G, Sings, HL, James, MK & Haupt, RM 2012, 'Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease', Journal of Infectious Diseases, pp. 1887-1896. https://doi.org/10.1093/infdis/jis612

Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. / Ruiz, Ángela María; Ruiz, Jaime Enrique; Gavilanes, Andrés Velásquez; Eriksson, Tiina; Lehtinen, Matti; Pérez, Gonzalo; Sings, Heather L.; James, Margaret K.; Haupt, Richard M.

En: Journal of Infectious Diseases, 15.12.2012, p. 1887-1896.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease

AU - Ruiz, Ángela María

AU - Ruiz, Jaime Enrique

AU - Gavilanes, Andrés Velásquez

AU - Eriksson, Tiina

AU - Lehtinen, Matti

AU - Pérez, Gonzalo

AU - Sings, Heather L.

AU - James, Margaret K.

AU - Haupt, Richard M.

PY - 2012/12/15

Y1 - 2012/12/15

N2 - Background We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95% CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. © 2012 The Author.

AB - Background We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95% CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. © 2012 The Author.

U2 - 10.1093/infdis/jis612

DO - 10.1093/infdis/jis612

M3 - Article

C2 - 23066159

SP - 1887

EP - 1896

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

ER -