Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components

Magnolia Vanegas, Adriana Bermúdez, Yuly Andrea Guerrero, Jesús Alfredo Cortes-Vecino, Hernando Curtidor, Manuel Elkin Patarroyo, José Manuel Lozano

Resultado de la investigación: Contribución a RevistaArtículo

1 Cita (Scopus)

Resumen

Developing novel generations of subunit-based antimalarial vaccines in the form of chemically-defined macromolecule systems for multiple antigen presentation represents a classical problem in the field of vaccine development. Many efforts involving synthesis strategies leading to macromolecule constructs have been based on dendrimer-like systems, the condensation of large building blocks and conventional asymmetric double dimer constructs, all based on lysine cores. This work describes novel symmetric double dimer and condensed linear constructs for presenting selected peptide multi-copies from the apical sushi protein expressed in Plasmodium falciparum. These molecules have been proved to be safe and innocuous, highly antigenic and have shown strong protective efficacy in rodents challenged with two Plasmodium species. Insights into systematic design, synthesis and characterisation have led to such novel antigen systems being used as potential platforms for developing new anti-malarial vaccine candidates.

Idioma originalEnglish (US)
Páginas (desde-hasta)15-23
Número de páginas9
PublicaciónBiochemical and Biophysical Research Communications
Volumen451
N.º1
DOI
EstadoPublished - ago 15 2014
Publicado de forma externa

Huella dactilar

Antimalarials
Plasmodium falciparum
Macromolecules
Dimers
Malaria
Vaccines
Malaria Vaccines
Antigens
Dendrimers
Plasmodium
Antigen Presentation
Lysine
Condensation
Rodentia
Proteins
Peptides
Molecules

Citar esto

Vanegas, Magnolia ; Bermúdez, Adriana ; Guerrero, Yuly Andrea ; Cortes-Vecino, Jesús Alfredo ; Curtidor, Hernando ; Patarroyo, Manuel Elkin ; Lozano, José Manuel. / Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components. En: Biochemical and Biophysical Research Communications. 2014 ; Vol. 451, N.º 1. pp. 15-23.
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abstract = "Developing novel generations of subunit-based antimalarial vaccines in the form of chemically-defined macromolecule systems for multiple antigen presentation represents a classical problem in the field of vaccine development. Many efforts involving synthesis strategies leading to macromolecule constructs have been based on dendrimer-like systems, the condensation of large building blocks and conventional asymmetric double dimer constructs, all based on lysine cores. This work describes novel symmetric double dimer and condensed linear constructs for presenting selected peptide multi-copies from the apical sushi protein expressed in Plasmodium falciparum. These molecules have been proved to be safe and innocuous, highly antigenic and have shown strong protective efficacy in rodents challenged with two Plasmodium species. Insights into systematic design, synthesis and characterisation have led to such novel antigen systems being used as potential platforms for developing new anti-malarial vaccine candidates.",
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Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components. / Vanegas, Magnolia; Bermúdez, Adriana; Guerrero, Yuly Andrea; Cortes-Vecino, Jesús Alfredo; Curtidor, Hernando; Patarroyo, Manuel Elkin; Lozano, José Manuel.

En: Biochemical and Biophysical Research Communications, Vol. 451, N.º 1, 15.08.2014, p. 15-23.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components

AU - Vanegas, Magnolia

AU - Bermúdez, Adriana

AU - Guerrero, Yuly Andrea

AU - Cortes-Vecino, Jesús Alfredo

AU - Curtidor, Hernando

AU - Patarroyo, Manuel Elkin

AU - Lozano, José Manuel

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/8/15

Y1 - 2014/8/15

N2 - Developing novel generations of subunit-based antimalarial vaccines in the form of chemically-defined macromolecule systems for multiple antigen presentation represents a classical problem in the field of vaccine development. Many efforts involving synthesis strategies leading to macromolecule constructs have been based on dendrimer-like systems, the condensation of large building blocks and conventional asymmetric double dimer constructs, all based on lysine cores. This work describes novel symmetric double dimer and condensed linear constructs for presenting selected peptide multi-copies from the apical sushi protein expressed in Plasmodium falciparum. These molecules have been proved to be safe and innocuous, highly antigenic and have shown strong protective efficacy in rodents challenged with two Plasmodium species. Insights into systematic design, synthesis and characterisation have led to such novel antigen systems being used as potential platforms for developing new anti-malarial vaccine candidates.

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