Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy

systematic review

Título traducido de la contribución: Propiedades intrínsecas y cambios funcionales en el músculo espástico después de la aplicación de BTX-A en niños con parálisis cerebral: análisis sistemático

Luisa Fernanda García Salazar, Gabriela Lopes dos Santos, Silvia Letícia Pavão, Nelci Adriana Cicuto Ferreira Rocha, Thiago Luiz de Russo

Resultado de la investigación: Contribución a RevistaArtículo de revisión

7 Citas (Scopus)

Resumen

OBJETIVO: El objetivo de este artículo fue revisar la literatura para verificar el efecto de la toxina botulínica tipo A (BTX-A) sobre las propiedades intrínsecas de los músculos espásticos y la funcionalidad en niños con parálisis cerebral (PC).

MÉTODOS: Se realizó una búsqueda bibliográfica en las siguientes bases de datos: CINAHL, SCOPUS, Web of Science y PubMed. Las búsquedas en las bases de datos se limitaron al período comprendido entre enero de 1993 y marzo de 2014.

RESULTADOS: Se identificaron un total de 2182 artículos y 17 cumplieron con los criterios de inclusión. Sólo un estudio analizó el efecto de la toxina sobre las propiedades intrínsecas del músculo y otros analizaron el efecto sobre la funcionalidad.

CONCLUSIÓN: La aplicación de BTX-A no demostró cambios en la rigidez pasiva del músculo espástico. En relación con el nivel funcional, las pruebas del efecto BTX-A fueron controvertidas. Estos estudios mostraron limitaciones de calidad metodológica que restringen la interpretación de los resultados para toda la población con parálisis cerebral, lo que justifica la necesidad de ensayos controlados aleatorios adicionales.

Idioma originalEnglish (US)
Páginas (desde-hasta)1-14
Número de páginas14
PublicaciónDevelopmental Neurorehabilitation
Volumen18
N.º1
DOI
EstadoPublished - feb 1 2015

Huella dactilar

Type A Botulinum Toxins
Muscle Spasticity
Cerebral Palsy
Muscles
Databases
PubMed
Randomized Controlled Trials
Population

Citar esto

García Salazar, Luisa Fernanda ; dos Santos, Gabriela Lopes ; Pavão, Silvia Letícia ; Rocha, Nelci Adriana Cicuto Ferreira ; de Russo, Thiago Luiz. / Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy : systematic review. En: Developmental Neurorehabilitation. 2015 ; Vol. 18, N.º 1. pp. 1-14.
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abstract = "OBJECTIVE: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP).METHODS: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014.RESULTS: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality.CONCLUSION: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.",
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Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy : systematic review. / García Salazar, Luisa Fernanda; dos Santos, Gabriela Lopes; Pavão, Silvia Letícia; Rocha, Nelci Adriana Cicuto Ferreira; de Russo, Thiago Luiz.

En: Developmental Neurorehabilitation, Vol. 18, N.º 1, 01.02.2015, p. 1-14.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy

T2 - systematic review

AU - García Salazar, Luisa Fernanda

AU - dos Santos, Gabriela Lopes

AU - Pavão, Silvia Letícia

AU - Rocha, Nelci Adriana Cicuto Ferreira

AU - de Russo, Thiago Luiz

PY - 2015/2/1

Y1 - 2015/2/1

N2 - OBJECTIVE: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP).METHODS: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014.RESULTS: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality.CONCLUSION: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.

AB - OBJECTIVE: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP).METHODS: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014.RESULTS: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality.CONCLUSION: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.

U2 - 10.3109/17518423.2014.948640

DO - 10.3109/17518423.2014.948640

M3 - Review article

VL - 18

SP - 1

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JO - Developmental Neurorehabilitation

JF - Developmental Neurorehabilitation

SN - 1751-8423

IS - 1

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