Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?

doi:10.1007/s00787-023-02196-7

Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?

Título traducido de la contribución: Síntomas prodrómicos y duración de la psicosis no tratada en pacientes con primer episodio de psicosis: ¿qué diferencias hay entre la aparición precoz y la adulta y entre la esquizofrenia y el trastorno bipolar?

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7 Citas (Scopus)

Resumen

Evaluar el papel de la edad (psicosis de inicio precoz-EOP < 18 años frente a psicosis de inicio adulto-AOP) y el diagnóstico (trastornos del espectro esquizofrénico-SSD frente a trastornos bipolares-BD) en la duración de la psicosis no tratada (DUP) y los síntomas prodrómicos en una muestra de pacientes con un primer episodio de psicosis. Se reclutaron 331 pacientes con un primer episodio de psicosis (7-35 años) y 174 (52,6%) fueron diagnosticados de SSD o BD en el seguimiento de un año a través de un estudio longitudinal multicéntrico. Se administraron el inventario de Síntomas de Inicio en la Esquizofrenia (SOS), la Escala de Síndrome Positivo y Negativo y las entrevistas clínicas estructuradas para los diagnósticos DSM-IV. Los modelos lineales generalizados compararon los efectos principales y la interacción de grupo. Se incluyeron 273 pacientes AOP (25,2 ± 5,1 años; 66,5% varones) y 58 pacientes EOP (15,5 ± 1,8 años; 70,7% varones). Los pacientes con EOP presentaban significativamente más síntomas prodrómicos con una mayor frecuencia de problemas para pensar, avolición y alucinaciones que los pacientes con AOP, y una mediana de DUP significativamente diferente (91 [33-177] frente a 58 [21-140] días; Z = - 2,006, p = 0,045). Esto también fue significativamente más largo en los pacientes con SSD frente a los pacientes con BD (90 [31-155] frente a 30 [7-66] días; Z = - 2,916, p = 0,004) que, además, tenían diferentes perfiles de síntomas prodrómicos. Al evaluar la interacción entre la edad de inicio (EOP/AOP) y el tipo de diagnóstico (SSD/BD), la avolición fue significativamente mayor (estadístico de Wald = 3,945; p = 0,047), en los pacientes AOP con SSD en comparación con los pacientes AOP BD (p = 0,004). El conocimiento de las diferencias en la duración del DUP y los síntomas prodrómicos en los pacientes EOP frente a AOP y SSD frente a BD podría ayudar a mejorar la detección precoz de la psicosis entre los menores.

Título traducido de la contribución	Síntomas prodrómicos y duración de la psicosis no tratada en pacientes con primer episodio de psicosis: ¿qué diferencias hay entre la aparición precoz y la adulta y entre la esquizofrenia y el trastorno bipolar?
Idioma original	Inglés estadounidense
Publicación	European Child and Adolescent Psychiatry
DOI	https://doi.org/10.1007/s00787-023-02196-7
Estado	Publicada - abr. 7 2023

Áreas temáticas de ASJC Scopus

Pediatría, perinaltología y salud infantil
Psicología educativa y evolutiva
Psiquiatría y salud mental

ODS de las Naciones Unidas

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@article{3f26b708162f43fd8b46ab02bcc023c6,

title = "Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?",

abstract = "To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7–35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33–177] vs. 58 [21–140] days; Z = − 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31–155] vs. 30 [7–66] days; Z = − 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.",

author = "Inmaculada Baeza and {de la Serna}, Elena and Gisela Mezquida and Cuesta, {Manuel J.} and Eduard Vieta and Silvia Amoretti and Antonio Lobo and Ana Gonz{\'a}lez-Pinto and D{\'i}az-Caneja, {Covadonga M.} and Iluminada Corripio and Isabel Valli and Olga Puig and Anna Man{\'e} and Miquel Bioque and Miriam Ayora and Miquel Bernardo and Josefina Castro-Fornieles and Clemente Garc{\'i}a-Rizo and Jairo Gonz{\'a}lez-D{\'i}az and {de Matteis}, Mario and {de Diego}, H{\'e}ctor and Eva Grasa and Alejandra Rold{\'a}n and I{\~n}aki Zorrilla and Edurne Garc{\'i}a-Corres and Ru{\'i}z-L{\'a}zaro, {Pedro M.} and Concepci{\'o}n de-la-C{\'a}mara and Olga Rivero and Escarti, {Mar{\'i}a Jos{\'e}} and Francesc Casanovas and Alba Toll and Norma Verdolini and Maria Sagu{\'e}-Vilabella and Gisela Sugranyes and Daniel Ilzarbe and Fernando Contreras and Leticia Gonz{\'a}lez-Blanco and Garc{\'i}a-Portilla, {Mar{\'i}a Paz} and Miguel Gutierrez and Arantzazu Zabala and Roberto Rodr{\'i}guez-Jim{\'e}nez and Luis S{\'a}nchez-Pastor and Judith Usall and Anna Butjosa and Edith Pomarol and Salvador Sarr{\'o} and Angela Ib{\'a}{\~n}ez and S{\'a}nchez-Torres, {Ana Maria} and Vicent Balanz{\'a}-Mart{\'i}nez",

note = "Funding Information: The PEPs Study is a coordinated-multicentre project funded by the Ministerio de Econom{\'i}a y Competitividad (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – Fondo Europeo de Desarrollo Regional. Uni{\'o}n Europea.“Una manera de hacer Europa”, cofinanciado por la Uni{\'o}n Europea, Centro de Investigaci{\'o}n Biom{\'e}dica en Red de salud Mental, CIBERSAM, the CERCA Program / Generalitat de Catalunya and Secretaria d{\textquoteright}Universitats i Recerca del Departament d{\textquoteright}Economia I Coneixement (2017SGR1355, 2017SGR881). Departament de Salut de la Generalitat de Catalunya, Pla Estrat{\`e}gic de Recerca i Innovaci{\'o} en Salut (PERIS) 2016-2020 (SLT006/17/00345). The authors would like to thank the patients and families who collaborated in the study, Mr. R. Borras for his statistical advice, and Mr. A.D. Pierce for his English editorial assistance. Previous presentations: Poster presented at the European College of Neuropsychopharmacology (ECNP) annual meeting, Barcelona, Spain, October 6-9, 2018. Oral communication presented at the XXI Spanish Psychiatry Conference (Congreso Nacional de Psiquiatr{\'i}a), Granada, Espa{\~n}a, October 18–20, 2018. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = apr,

day = "7",

doi = "10.1007/s00787-023-02196-7",

language = "English (US)",

journal = "European Child and Adolescent Psychiatry",

issn = "1018-8827",

publisher = "D. Steinkopff-Verlag",

}

Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder? /.
En: European Child and Adolescent Psychiatry, 07.04.2023.

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients

T2 - what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?

AU - Baeza, Inmaculada

AU - de la Serna, Elena

AU - Mezquida, Gisela

AU - Cuesta, Manuel J.

AU - Vieta, Eduard

AU - Amoretti, Silvia

AU - Lobo, Antonio

AU - González-Pinto, Ana

AU - Díaz-Caneja, Covadonga M.

AU - Corripio, Iluminada

AU - Valli, Isabel

AU - Puig, Olga

AU - Mané, Anna

AU - Bioque, Miquel

AU - Ayora, Miriam

AU - Bernardo, Miquel

AU - Castro-Fornieles, Josefina

AU - García-Rizo, Clemente

AU - González-Díaz, Jairo

AU - de Matteis, Mario

AU - de Diego, Héctor

AU - Grasa, Eva

AU - Roldán, Alejandra

AU - Zorrilla, Iñaki

AU - García-Corres, Edurne

AU - Ruíz-Lázaro, Pedro M.

AU - de-la-Cámara, Concepción

AU - Rivero, Olga

AU - Escarti, María José

AU - Casanovas, Francesc

AU - Toll, Alba

AU - Verdolini, Norma

AU - Sagué-Vilabella, Maria

AU - Sugranyes, Gisela

AU - Ilzarbe, Daniel

AU - Contreras, Fernando

AU - González-Blanco, Leticia

AU - García-Portilla, María Paz

AU - Gutierrez, Miguel

AU - Zabala, Arantzazu

AU - Rodríguez-Jiménez, Roberto

AU - Sánchez-Pastor, Luis

AU - Usall, Judith

AU - Butjosa, Anna

AU - Pomarol, Edith

AU - Sarró, Salvador

AU - Ibáñez, Angela

AU - Sánchez-Torres, Ana Maria

AU - Balanzá-Martínez, Vicent

N1 - Funding Information: The PEPs Study is a coordinated-multicentre project funded by the Ministerio de Economía y Competitividad (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – Fondo Europeo de Desarrollo Regional. Unión Europea.“Una manera de hacer Europa”, cofinanciado por la Unión Europea, Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, the CERCA Program / Generalitat de Catalunya and Secretaria d’Universitats i Recerca del Departament d’Economia I Coneixement (2017SGR1355, 2017SGR881). Departament de Salut de la Generalitat de Catalunya, Pla Estratègic de Recerca i Innovació en Salut (PERIS) 2016-2020 (SLT006/17/00345). The authors would like to thank the patients and families who collaborated in the study, Mr. R. Borras for his statistical advice, and Mr. A.D. Pierce for his English editorial assistance. Previous presentations: Poster presented at the European College of Neuropsychopharmacology (ECNP) annual meeting, Barcelona, Spain, October 6-9, 2018. Oral communication presented at the XXI Spanish Psychiatry Conference (Congreso Nacional de Psiquiatría), Granada, España, October 18–20, 2018. Publisher Copyright: © 2023, The Author(s).

PY - 2023/4/7

Y1 - 2023/4/7

N2 - To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7–35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33–177] vs. 58 [21–140] days; Z = − 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31–155] vs. 30 [7–66] days; Z = − 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.

AB - To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7–35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33–177] vs. 58 [21–140] days; Z = − 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31–155] vs. 30 [7–66] days; Z = − 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.

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U2 - 10.1007/s00787-023-02196-7

DO - 10.1007/s00787-023-02196-7

M3 - Research Article

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AN - SCOPUS:85152432138

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JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

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