Proceso biológico del desarrollo epifisario: Aparición y formación del centro secundario de osificación

Bones are the specialized connective tissue shaping the main support organ of the body. Long bone epiphysis underwent many structural changes during the perinatal period leading to formation of a secondary center of ossification (SCO), accounting for the epiphyseal spherical growth. In present paper are exposed the characteristic biological changes of the different SCO development stages thorough a detailed description of histological events occurring in each stage and illustrating the processes coordination and the epiphyseal development pattern. Therefore, present article will allows the understanding of such processes, creation of mathematical models of different events, as well as a theoretical basis for future papers researching the epiphyseal development and growth.