Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis

Dana Ben Ami Shor, Guy A. Weiss, Ori Barzilai, Maya Ram, Juan Manuel Anaya, Yehuda Shoenfeld, Yaniv Sherer

Resultado de la investigación: Contribución a RevistaArtículo

5 Citas (Scopus)

Resumen

BACKGROUND: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.

OBJECTIVES: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.

METHODS: Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.

RESULTS: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.

CONCLUSIONS: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

Idioma originalEnglish (US)
Páginas (desde-hasta)559-62
Número de páginas4
PublicaciónIsrael Medical Association Journal
Volumen17
N.º9
EstadoPublished - sep 2015

Huella dactilar

Antiphospholipid Antibodies
Prothrombin
Multiple Sclerosis
Immunoglobulin G
Immunoglobulin M
Phosphatidylserines
Immunoassay
Autoantibodies
Control Groups
Antibodies
Serum

Citar esto

Shor, D. B. A., Weiss, G. A., Barzilai, O., Ram, M., Anaya, J. M., Shoenfeld, Y., & Sherer, Y. (2015). Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis. Israel Medical Association Journal, 17(9), 559-62.
Shor, Dana Ben Ami ; Weiss, Guy A. ; Barzilai, Ori ; Ram, Maya ; Anaya, Juan Manuel ; Shoenfeld, Yehuda ; Sherer, Yaniv. / Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis. En: Israel Medical Association Journal. 2015 ; Vol. 17, N.º 9. pp. 559-62.
@article{ae33d9f879b3451091c3048ffcf74f8c,
title = "Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis",
abstract = "BACKGROUND: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.OBJECTIVES: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.METHODS: Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.RESULTS: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.CONCLUSIONS: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.",
author = "Shor, {Dana Ben Ami} and Weiss, {Guy A.} and Ori Barzilai and Maya Ram and Anaya, {Juan Manuel} and Yehuda Shoenfeld and Yaniv Sherer",
year = "2015",
month = "9",
language = "English (US)",
volume = "17",
pages = "559--62",
journal = "Israel Medical Association Journal",
issn = "1565-1088",
publisher = "Israel Medical Association",
number = "9",

}

Shor, DBA, Weiss, GA, Barzilai, O, Ram, M, Anaya, JM, Shoenfeld, Y & Sherer, Y 2015, 'Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis', Israel Medical Association Journal, vol. 17, n.º 9, pp. 559-62.

Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis. / Shor, Dana Ben Ami; Weiss, Guy A.; Barzilai, Ori; Ram, Maya; Anaya, Juan Manuel; Shoenfeld, Yehuda; Sherer, Yaniv.

En: Israel Medical Association Journal, Vol. 17, N.º 9, 09.2015, p. 559-62.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis

AU - Shor, Dana Ben Ami

AU - Weiss, Guy A.

AU - Barzilai, Ori

AU - Ram, Maya

AU - Anaya, Juan Manuel

AU - Shoenfeld, Yehuda

AU - Sherer, Yaniv

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.OBJECTIVES: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.METHODS: Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.RESULTS: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.CONCLUSIONS: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

AB - BACKGROUND: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.OBJECTIVES: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.METHODS: Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.RESULTS: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.CONCLUSIONS: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

M3 - Article

C2 - 26625546

VL - 17

SP - 559

EP - 562

JO - Israel Medical Association Journal

JF - Israel Medical Association Journal

SN - 1565-1088

IS - 9

ER -