Prevalence of celiac disease in Latin America: A systematic review and meta-regression

Rafael Parra-Medina, Nicolás Molano-Gonzalez, Adriana Rojas-Villarraga, Nancy Agmon-Levin, Maria Teresa Arango, Yehuda Shoenfeld, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

20 Citas (Scopus)

Resumen

© 2015 Parra-Medina et al.Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.
Idioma originalEnglish (US)
PublicaciónPLoS One
Volumen10
N.º5
DOI
EstadoPublished - may 5 2015

Huella dactilar

celiac disease
Latin America
systematic review
Celiac Disease
Meta-Analysis
Population
autoimmunity
autoantibodies
insulin-dependent diabetes mellitus
Glutens
protein-glutamine gamma-glutamyltransferase
disease prevalence
Biopsy
digestive system diseases
gluten
Autoimmunity
Type 1 Diabetes Mellitus
meta-analysis
cross-sectional studies
abdomen

Citar esto

Parra-Medina, R., Molano-Gonzalez, N., Rojas-Villarraga, A., Agmon-Levin, N., Arango, M. T., Shoenfeld, Y., & Anaya, J. M. (2015). Prevalence of celiac disease in Latin America: A systematic review and meta-regression. PLoS One, 10(5). https://doi.org/10.1371/journal.pone.0124040
Parra-Medina, Rafael ; Molano-Gonzalez, Nicolás ; Rojas-Villarraga, Adriana ; Agmon-Levin, Nancy ; Arango, Maria Teresa ; Shoenfeld, Yehuda ; Anaya, Juan Manuel. / Prevalence of celiac disease in Latin America: A systematic review and meta-regression. En: PLoS One. 2015 ; Vol. 10, N.º 5.
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abstract = "{\circledC} 2015 Parra-Medina et al.Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46{\%}and 0.64{\%}. The prevalence of CD in firstdegree relatives of CD probands was 5.5{\%}. The coexistence of CD and type 1 diabetes mellitus varied from 4.6{\%} to 8.7{\%}, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.",
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Parra-Medina, R, Molano-Gonzalez, N, Rojas-Villarraga, A, Agmon-Levin, N, Arango, MT, Shoenfeld, Y & Anaya, JM 2015, 'Prevalence of celiac disease in Latin America: A systematic review and meta-regression', PLoS One, vol. 10, n.º 5. https://doi.org/10.1371/journal.pone.0124040

Prevalence of celiac disease in Latin America: A systematic review and meta-regression. / Parra-Medina, Rafael; Molano-Gonzalez, Nicolás; Rojas-Villarraga, Adriana; Agmon-Levin, Nancy; Arango, Maria Teresa; Shoenfeld, Yehuda; Anaya, Juan Manuel.

En: PLoS One, Vol. 10, N.º 5, 05.05.2015.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Parra-Medina, Rafael

AU - Molano-Gonzalez, Nicolás

AU - Rojas-Villarraga, Adriana

AU - Agmon-Levin, Nancy

AU - Arango, Maria Teresa

AU - Shoenfeld, Yehuda

AU - Anaya, Juan Manuel

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N2 - © 2015 Parra-Medina et al.Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.

AB - © 2015 Parra-Medina et al.Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.

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VL - 10

JO - PLoS One

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SN - 1932-6203

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Parra-Medina R, Molano-Gonzalez N, Rojas-Villarraga A, Agmon-Levin N, Arango MT, Shoenfeld Y y otros. Prevalence of celiac disease in Latin America: A systematic review and meta-regression. PLoS One. 2015 may 5;10(5). https://doi.org/10.1371/journal.pone.0124040