Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases

Yinon Shapira, Nancy Agmon-Levin, Carlo Selmi, Jana Petríková, Ori Barzilai, Maya Ram, Nicola Bizzaro, Gabriele Valentini, Marco Matucci-Cerinic, Juan Manuel Anaya, Bat sheva Porat Katz, Yehuda Shoenfeld

Resultado de la investigación: Contribución a RevistaArtículo

33 Citas (Scopus)

Resumen

The identification of etiological factors in the induction of autoimmunity has remained elusive despite an enormous effort at dissection of the molecular structure of the target antigens and effector mechanisms. One characteristic feature of autoantigens is their repetitive structure as well as their conservation and evolution. Toxoplasma (T.) gondii is a primitive protozoan. We hypothesized that patients with autoimmune disease would have broad reactions against Toxoplasma antigens based on autoantigen conservation.To address this issue, we assessed serologic evidence of reactivity to Toxoplasma gondii along with a large profile of autoantibodies in patients with various autoimmune diseases (AID). We included sera of 1514 patients with 11 different AID collected from referral centers in Europe and Latin America as well as from 437 geographically matched controls, for the prevalence of anti Toxoplasma antibodies (ATxA) IgG and IgM and serum autoantibodies utilizing the BioPlex 2200 system (Bio- Rad Laboratories, USA).Serum ATxA IgG were positive in 42% of patients with AID versus 29% of controls (p <0.0001). Among Europeans, ATxA IgG were associated with anti-phospholipid syndrome (APS; p <0.0001), cryoglobulinemia (p <0.0001), ANCA-associated vasculitides (p <0.01), autoimmune thyroid diseases (p <0.0001), systemic sclerosis (SSc; p <0.0001) and rheumatoid arthritis (RA; p <0.0001). Of note, Latin American RA sera exhibited similar frequency of ATxA IgG as controls. ATxA IgM were more prevalent in European patients with APS (p <0.01), SSc (p <0.05) and inflammatory bowel disease (IBD, p <0.05) than in controls. Further, in AID patients the presence of ATxA correlated with autoantibodies characteristic of APS (anti- cardiolipin, B2GPI, complex of cardiolipin- B2GPI, prothrombin, phosphatydilethanolamine), and of SSc (anti-centromere, Scl-70).Our findings suggest that T. gondii may contribute to the pathogenesis of AID. This interaction may depend on or explain observed geoepidemiological variance in AID. © 2012 Elsevier Ltd.
Idioma originalEnglish (US)
Páginas (desde-hasta)112-116
Número de páginas5
PublicaciónJournal of Autoimmunity
DOI
EstadoPublished - ago 1 2012

Huella dactilar

Toxoplasma
Autoimmune Diseases
Anti-Idiotypic Antibodies
Immunoglobulin G
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Autoantibodies
Cardiolipins
Autoantigens
Serum
Immunoglobulin M
Antigens
Cryoglobulinemia
Antiphospholipid Syndrome
Latin America
Centromere
Systemic Scleroderma
Thyroid Diseases
Prothrombin
Molecular Structure
Autoimmunity

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Shapira, Y., Agmon-Levin, N., Selmi, C., Petríková, J., Barzilai, O., Ram, M., ... Shoenfeld, Y. (2012). Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases. Journal of Autoimmunity, 112-116. https://doi.org/10.1016/j.jaut.2012.01.001
Shapira, Yinon ; Agmon-Levin, Nancy ; Selmi, Carlo ; Petríková, Jana ; Barzilai, Ori ; Ram, Maya ; Bizzaro, Nicola ; Valentini, Gabriele ; Matucci-Cerinic, Marco ; Anaya, Juan Manuel ; Katz, Bat sheva Porat ; Shoenfeld, Yehuda. / Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases. En: Journal of Autoimmunity. 2012 ; pp. 112-116.
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title = "Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases",
abstract = "The identification of etiological factors in the induction of autoimmunity has remained elusive despite an enormous effort at dissection of the molecular structure of the target antigens and effector mechanisms. One characteristic feature of autoantigens is their repetitive structure as well as their conservation and evolution. Toxoplasma (T.) gondii is a primitive protozoan. We hypothesized that patients with autoimmune disease would have broad reactions against Toxoplasma antigens based on autoantigen conservation.To address this issue, we assessed serologic evidence of reactivity to Toxoplasma gondii along with a large profile of autoantibodies in patients with various autoimmune diseases (AID). We included sera of 1514 patients with 11 different AID collected from referral centers in Europe and Latin America as well as from 437 geographically matched controls, for the prevalence of anti Toxoplasma antibodies (ATxA) IgG and IgM and serum autoantibodies utilizing the BioPlex 2200 system (Bio- Rad Laboratories, USA).Serum ATxA IgG were positive in 42{\%} of patients with AID versus 29{\%} of controls (p <0.0001). Among Europeans, ATxA IgG were associated with anti-phospholipid syndrome (APS; p <0.0001), cryoglobulinemia (p <0.0001), ANCA-associated vasculitides (p <0.01), autoimmune thyroid diseases (p <0.0001), systemic sclerosis (SSc; p <0.0001) and rheumatoid arthritis (RA; p <0.0001). Of note, Latin American RA sera exhibited similar frequency of ATxA IgG as controls. ATxA IgM were more prevalent in European patients with APS (p <0.01), SSc (p <0.05) and inflammatory bowel disease (IBD, p <0.05) than in controls. Further, in AID patients the presence of ATxA correlated with autoantibodies characteristic of APS (anti- cardiolipin, B2GPI, complex of cardiolipin- B2GPI, prothrombin, phosphatydilethanolamine), and of SSc (anti-centromere, Scl-70).Our findings suggest that T. gondii may contribute to the pathogenesis of AID. This interaction may depend on or explain observed geoepidemiological variance in AID. {\circledC} 2012 Elsevier Ltd.",
author = "Yinon Shapira and Nancy Agmon-Levin and Carlo Selmi and Jana Petr{\'i}kov{\'a} and Ori Barzilai and Maya Ram and Nicola Bizzaro and Gabriele Valentini and Marco Matucci-Cerinic and Anaya, {Juan Manuel} and Katz, {Bat sheva Porat} and Yehuda Shoenfeld",
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Shapira, Y, Agmon-Levin, N, Selmi, C, Petríková, J, Barzilai, O, Ram, M, Bizzaro, N, Valentini, G, Matucci-Cerinic, M, Anaya, JM, Katz, BSP & Shoenfeld, Y 2012, 'Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases', Journal of Autoimmunity, pp. 112-116. https://doi.org/10.1016/j.jaut.2012.01.001

Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases. / Shapira, Yinon; Agmon-Levin, Nancy; Selmi, Carlo; Petríková, Jana; Barzilai, Ori; Ram, Maya; Bizzaro, Nicola; Valentini, Gabriele; Matucci-Cerinic, Marco; Anaya, Juan Manuel; Katz, Bat sheva Porat; Shoenfeld, Yehuda.

En: Journal of Autoimmunity, 01.08.2012, p. 112-116.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases

AU - Shapira, Yinon

AU - Agmon-Levin, Nancy

AU - Selmi, Carlo

AU - Petríková, Jana

AU - Barzilai, Ori

AU - Ram, Maya

AU - Bizzaro, Nicola

AU - Valentini, Gabriele

AU - Matucci-Cerinic, Marco

AU - Anaya, Juan Manuel

AU - Katz, Bat sheva Porat

AU - Shoenfeld, Yehuda

PY - 2012/8/1

Y1 - 2012/8/1

N2 - The identification of etiological factors in the induction of autoimmunity has remained elusive despite an enormous effort at dissection of the molecular structure of the target antigens and effector mechanisms. One characteristic feature of autoantigens is their repetitive structure as well as their conservation and evolution. Toxoplasma (T.) gondii is a primitive protozoan. We hypothesized that patients with autoimmune disease would have broad reactions against Toxoplasma antigens based on autoantigen conservation.To address this issue, we assessed serologic evidence of reactivity to Toxoplasma gondii along with a large profile of autoantibodies in patients with various autoimmune diseases (AID). We included sera of 1514 patients with 11 different AID collected from referral centers in Europe and Latin America as well as from 437 geographically matched controls, for the prevalence of anti Toxoplasma antibodies (ATxA) IgG and IgM and serum autoantibodies utilizing the BioPlex 2200 system (Bio- Rad Laboratories, USA).Serum ATxA IgG were positive in 42% of patients with AID versus 29% of controls (p <0.0001). Among Europeans, ATxA IgG were associated with anti-phospholipid syndrome (APS; p <0.0001), cryoglobulinemia (p <0.0001), ANCA-associated vasculitides (p <0.01), autoimmune thyroid diseases (p <0.0001), systemic sclerosis (SSc; p <0.0001) and rheumatoid arthritis (RA; p <0.0001). Of note, Latin American RA sera exhibited similar frequency of ATxA IgG as controls. ATxA IgM were more prevalent in European patients with APS (p <0.01), SSc (p <0.05) and inflammatory bowel disease (IBD, p <0.05) than in controls. Further, in AID patients the presence of ATxA correlated with autoantibodies characteristic of APS (anti- cardiolipin, B2GPI, complex of cardiolipin- B2GPI, prothrombin, phosphatydilethanolamine), and of SSc (anti-centromere, Scl-70).Our findings suggest that T. gondii may contribute to the pathogenesis of AID. This interaction may depend on or explain observed geoepidemiological variance in AID. © 2012 Elsevier Ltd.

AB - The identification of etiological factors in the induction of autoimmunity has remained elusive despite an enormous effort at dissection of the molecular structure of the target antigens and effector mechanisms. One characteristic feature of autoantigens is their repetitive structure as well as their conservation and evolution. Toxoplasma (T.) gondii is a primitive protozoan. We hypothesized that patients with autoimmune disease would have broad reactions against Toxoplasma antigens based on autoantigen conservation.To address this issue, we assessed serologic evidence of reactivity to Toxoplasma gondii along with a large profile of autoantibodies in patients with various autoimmune diseases (AID). We included sera of 1514 patients with 11 different AID collected from referral centers in Europe and Latin America as well as from 437 geographically matched controls, for the prevalence of anti Toxoplasma antibodies (ATxA) IgG and IgM and serum autoantibodies utilizing the BioPlex 2200 system (Bio- Rad Laboratories, USA).Serum ATxA IgG were positive in 42% of patients with AID versus 29% of controls (p <0.0001). Among Europeans, ATxA IgG were associated with anti-phospholipid syndrome (APS; p <0.0001), cryoglobulinemia (p <0.0001), ANCA-associated vasculitides (p <0.01), autoimmune thyroid diseases (p <0.0001), systemic sclerosis (SSc; p <0.0001) and rheumatoid arthritis (RA; p <0.0001). Of note, Latin American RA sera exhibited similar frequency of ATxA IgG as controls. ATxA IgM were more prevalent in European patients with APS (p <0.01), SSc (p <0.05) and inflammatory bowel disease (IBD, p <0.05) than in controls. Further, in AID patients the presence of ATxA correlated with autoantibodies characteristic of APS (anti- cardiolipin, B2GPI, complex of cardiolipin- B2GPI, prothrombin, phosphatydilethanolamine), and of SSc (anti-centromere, Scl-70).Our findings suggest that T. gondii may contribute to the pathogenesis of AID. This interaction may depend on or explain observed geoepidemiological variance in AID. © 2012 Elsevier Ltd.

U2 - 10.1016/j.jaut.2012.01.001

DO - 10.1016/j.jaut.2012.01.001

M3 - Article

SP - 112

EP - 116

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

ER -

Shapira Y, Agmon-Levin N, Selmi C, Petríková J, Barzilai O, Ram M y otros. Prevalence of anti-toxoplasma antibodies in patients with autoimmune diseases. Journal of Autoimmunity. 2012 ago 1;112-116. https://doi.org/10.1016/j.jaut.2012.01.001