Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss

Magalie Vatin, Sylvie Bouvier, Linda Bellazi, Xavier Montagutelli, Paul Laissue, Ahmed Ziyyat, Catherine Serres, Philippe De Mazancourt, Marie Noelle Dieudonné, Etienne Mornet, Daniel Vaiman, Jean Christophe Gris

Resultado de la investigación: Contribución a RevistaArtículo

12 Citas (Scopus)

Resumen

Fertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in recurrent spontaneous abortion. We then analyzed patients for detecting putative associations between ALPP polymorphisms, in vitro fertilization failures, and miscarriages. ALPP was sequenced in 100 controls and 100 patients affected by recurrent spontaneous abortion, from the same ethnic background. The frequency of several alleles and allelic combinations were different between recurrent spontaneous abortion and control women. One polymorphism induced a coding substitution (Ile89Leu) that was associated with a decreased risk of abortion and in vitro fertilization failure. Thereafter, the population was increased by the analysis of 92 additional controls and 612 additional patients for the coding polymorphism Ile89Leu. We finally show, by functional analysis, that the 89Leu placental alkaline phosphatase has an enhanced alkaline phosphatase activity. This study suggests that ALPP genotyping could be a strong predictor of implantation success. © 2014 American Society for Investigative Pathology.
Idioma originalEnglish (US)
Páginas (desde-hasta)362-368
Número de páginas7
PublicaciónAmerican Journal of Pathology
DOI
EstadoPublished - feb 1 2014

Huella dactilar

Fertilization in Vitro
Spontaneous Abortion
Habitual Abortion
Pregnancy
Gene Frequency
Infertility
Genes
Fertility
Alkaline Phosphatase
placental alkaline phosphatase
Organism Cloning
Population

Citar esto

Vatin, Magalie ; Bouvier, Sylvie ; Bellazi, Linda ; Montagutelli, Xavier ; Laissue, Paul ; Ziyyat, Ahmed ; Serres, Catherine ; De Mazancourt, Philippe ; Dieudonné, Marie Noelle ; Mornet, Etienne ; Vaiman, Daniel ; Gris, Jean Christophe. / Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss. En: American Journal of Pathology. 2014 ; pp. 362-368.
@article{1ee5daa4161f4f5d959db91b89a9f8d6,
title = "Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss",
abstract = "Fertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in recurrent spontaneous abortion. We then analyzed patients for detecting putative associations between ALPP polymorphisms, in vitro fertilization failures, and miscarriages. ALPP was sequenced in 100 controls and 100 patients affected by recurrent spontaneous abortion, from the same ethnic background. The frequency of several alleles and allelic combinations were different between recurrent spontaneous abortion and control women. One polymorphism induced a coding substitution (Ile89Leu) that was associated with a decreased risk of abortion and in vitro fertilization failure. Thereafter, the population was increased by the analysis of 92 additional controls and 612 additional patients for the coding polymorphism Ile89Leu. We finally show, by functional analysis, that the 89Leu placental alkaline phosphatase has an enhanced alkaline phosphatase activity. This study suggests that ALPP genotyping could be a strong predictor of implantation success. {\circledC} 2014 American Society for Investigative Pathology.",
author = "Magalie Vatin and Sylvie Bouvier and Linda Bellazi and Xavier Montagutelli and Paul Laissue and Ahmed Ziyyat and Catherine Serres and {De Mazancourt}, Philippe and Dieudonn{\'e}, {Marie Noelle} and Etienne Mornet and Daniel Vaiman and Gris, {Jean Christophe}",
year = "2014",
month = "2",
day = "1",
doi = "10.1016/j.ajpath.2013.10.024",
language = "English (US)",
pages = "362--368",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",

}

Vatin, M, Bouvier, S, Bellazi, L, Montagutelli, X, Laissue, P, Ziyyat, A, Serres, C, De Mazancourt, P, Dieudonné, MN, Mornet, E, Vaiman, D & Gris, JC 2014, 'Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss', American Journal of Pathology, pp. 362-368. https://doi.org/10.1016/j.ajpath.2013.10.024

Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss. / Vatin, Magalie; Bouvier, Sylvie; Bellazi, Linda; Montagutelli, Xavier; Laissue, Paul; Ziyyat, Ahmed; Serres, Catherine; De Mazancourt, Philippe; Dieudonné, Marie Noelle; Mornet, Etienne; Vaiman, Daniel; Gris, Jean Christophe.

En: American Journal of Pathology, 01.02.2014, p. 362-368.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss

AU - Vatin, Magalie

AU - Bouvier, Sylvie

AU - Bellazi, Linda

AU - Montagutelli, Xavier

AU - Laissue, Paul

AU - Ziyyat, Ahmed

AU - Serres, Catherine

AU - De Mazancourt, Philippe

AU - Dieudonné, Marie Noelle

AU - Mornet, Etienne

AU - Vaiman, Daniel

AU - Gris, Jean Christophe

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Fertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in recurrent spontaneous abortion. We then analyzed patients for detecting putative associations between ALPP polymorphisms, in vitro fertilization failures, and miscarriages. ALPP was sequenced in 100 controls and 100 patients affected by recurrent spontaneous abortion, from the same ethnic background. The frequency of several alleles and allelic combinations were different between recurrent spontaneous abortion and control women. One polymorphism induced a coding substitution (Ile89Leu) that was associated with a decreased risk of abortion and in vitro fertilization failure. Thereafter, the population was increased by the analysis of 92 additional controls and 612 additional patients for the coding polymorphism Ile89Leu. We finally show, by functional analysis, that the 89Leu placental alkaline phosphatase has an enhanced alkaline phosphatase activity. This study suggests that ALPP genotyping could be a strong predictor of implantation success. © 2014 American Society for Investigative Pathology.

AB - Fertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in recurrent spontaneous abortion. We then analyzed patients for detecting putative associations between ALPP polymorphisms, in vitro fertilization failures, and miscarriages. ALPP was sequenced in 100 controls and 100 patients affected by recurrent spontaneous abortion, from the same ethnic background. The frequency of several alleles and allelic combinations were different between recurrent spontaneous abortion and control women. One polymorphism induced a coding substitution (Ile89Leu) that was associated with a decreased risk of abortion and in vitro fertilization failure. Thereafter, the population was increased by the analysis of 92 additional controls and 612 additional patients for the coding polymorphism Ile89Leu. We finally show, by functional analysis, that the 89Leu placental alkaline phosphatase has an enhanced alkaline phosphatase activity. This study suggests that ALPP genotyping could be a strong predictor of implantation success. © 2014 American Society for Investigative Pathology.

U2 - 10.1016/j.ajpath.2013.10.024

DO - 10.1016/j.ajpath.2013.10.024

M3 - Article

C2 - 24296104

SP - 362

EP - 368

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

ER -