Polymorphism of TNF-alpha in autoimmunity and tuberculosis

Paula A. Correa, Luis M. Gómez, Juan Manuel Anaya

Resultado de la investigación: Contribución a una revistaArtículo

15 Citas (Scopus)

Resumen

Tumor necrosis factor alpha (TNF-alpha) has been incriminated in several autoimmune and infectious diseases. The influence of TNF-alpha -308 polymorphism was examined in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS) and tuberculosis. Genomic DNA from patients with RA (N=165), SLE (N=118), pSS (N=67), tuberculosis (N=138), as well as ethnic-matched controls (N=419) were characterized for the TNF-alpha -308 genetic polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. TNF2 allele was associated with RA (OR: 1.6, C.I.95% 1.2-2.3, p=0.008), SLE (OR: 2.3, 95%C.I. 1.6-3.3, p
Idioma originalInglés estadounidense
Páginas (desde-hasta)43-51
Número de páginas9
PublicaciónBiomédica : revista del Instituto Nacional de Salud
EstadoPublicada - ene 1 2004

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