Polymorphism of TNF-alpha in autoimmunity and tuberculosis

Paula A. Correa, Luis M. Gómez, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

15 Citas (Scopus)

Resumen

Tumor necrosis factor alpha (TNF-alpha) has been incriminated in several autoimmune and infectious diseases. The influence of TNF-alpha -308 polymorphism was examined in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS) and tuberculosis. Genomic DNA from patients with RA (N=165), SLE (N=118), pSS (N=67), tuberculosis (N=138), as well as ethnic-matched controls (N=419) were characterized for the TNF-alpha -308 genetic polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. TNF2 allele was associated with RA (OR: 1.6, C.I.95% 1.2-2.3, p=0.008), SLE (OR: 2.3, 95%C.I. 1.6-3.3, p
Idioma originalEnglish (US)
Páginas (desde-hasta)43-51
Número de páginas9
PublicaciónBiomédica : revista del Instituto Nacional de Salud
EstadoPublished - ene 1 2004

Huella dactilar

Autoimmunity
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Tuberculosis
Tumor Necrosis Factor-alpha
Sjogren's Syndrome
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Autoimmune Diseases
Communicable Diseases
Alleles
Polymerase Chain Reaction
DNA

Citar esto

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title = "Polymorphism of TNF-alpha in autoimmunity and tuberculosis",
abstract = "Tumor necrosis factor alpha (TNF-alpha) has been incriminated in several autoimmune and infectious diseases. The influence of TNF-alpha -308 polymorphism was examined in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sj{\"o}gren's syndrome (pSS) and tuberculosis. Genomic DNA from patients with RA (N=165), SLE (N=118), pSS (N=67), tuberculosis (N=138), as well as ethnic-matched controls (N=419) were characterized for the TNF-alpha -308 genetic polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. TNF2 allele was associated with RA (OR: 1.6, C.I.95{\%} 1.2-2.3, p=0.008), SLE (OR: 2.3, 95{\%}C.I. 1.6-3.3, p",
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Polymorphism of TNF-alpha in autoimmunity and tuberculosis. / Correa, Paula A.; Gómez, Luis M.; Anaya, Juan Manuel.

En: Biomédica : revista del Instituto Nacional de Salud, 01.01.2004, p. 43-51.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Anaya, Juan Manuel

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