Polyautoimmunity and familial autoimmunity in systemic sclerosis

Marie Hudson, Adriana Rojas-Villarraga, Paola Coral-Alvarado, Silvia López-Guzmán, Ruben D. Mantilla, Philippe Chalem, Murray Baron, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

73 Citas (Scopus)

Resumen

Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38%) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38%), rheumatoid arthritis (RA, 21%), Sjögren's syndrome (18%), and primary biliary cirrhosis (4%). There were 260 (36%) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18%) and AITD (9%). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. © 2008 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)156-159
Número de páginas4
PublicaciónJournal of Autoimmunity
DOI
EstadoPublished - sep 1 2008

Huella dactilar

Systemic Scleroderma
Autoimmunity
Autoimmune Diseases
Colombia
Biliary Liver Cirrhosis
Sjogren's Syndrome
Thyroid Diseases
Canada
Rheumatoid Arthritis
Cross-Sectional Studies
Phenotype

Citar esto

Hudson, Marie ; Rojas-Villarraga, Adriana ; Coral-Alvarado, Paola ; López-Guzmán, Silvia ; Mantilla, Ruben D. ; Chalem, Philippe ; Baron, Murray ; Anaya, Juan Manuel. / Polyautoimmunity and familial autoimmunity in systemic sclerosis. En: Journal of Autoimmunity. 2008 ; pp. 156-159.
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abstract = "Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38{\%}) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38{\%}), rheumatoid arthritis (RA, 21{\%}), Sj{\"o}gren's syndrome (18{\%}), and primary biliary cirrhosis (4{\%}). There were 260 (36{\%}) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18{\%}) and AITD (9{\%}). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. {\circledC} 2008 Elsevier Ltd. All rights reserved.",
author = "Marie Hudson and Adriana Rojas-Villarraga and Paola Coral-Alvarado and Silvia L{\'o}pez-Guzm{\'a}n and Mantilla, {Ruben D.} and Philippe Chalem and Murray Baron and Anaya, {Juan Manuel}",
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Hudson, M, Rojas-Villarraga, A, Coral-Alvarado, P, López-Guzmán, S, Mantilla, RD, Chalem, P, Baron, M & Anaya, JM 2008, 'Polyautoimmunity and familial autoimmunity in systemic sclerosis', Journal of Autoimmunity, pp. 156-159. https://doi.org/10.1016/j.jaut.2008.05.002

Polyautoimmunity and familial autoimmunity in systemic sclerosis. / Hudson, Marie; Rojas-Villarraga, Adriana; Coral-Alvarado, Paola; López-Guzmán, Silvia; Mantilla, Ruben D.; Chalem, Philippe; Baron, Murray; Anaya, Juan Manuel.

En: Journal of Autoimmunity, 01.09.2008, p. 156-159.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Polyautoimmunity and familial autoimmunity in systemic sclerosis

AU - Hudson, Marie

AU - Rojas-Villarraga, Adriana

AU - Coral-Alvarado, Paola

AU - López-Guzmán, Silvia

AU - Mantilla, Ruben D.

AU - Chalem, Philippe

AU - Baron, Murray

AU - Anaya, Juan Manuel

PY - 2008/9/1

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N2 - Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38%) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38%), rheumatoid arthritis (RA, 21%), Sjögren's syndrome (18%), and primary biliary cirrhosis (4%). There were 260 (36%) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18%) and AITD (9%). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. © 2008 Elsevier Ltd. All rights reserved.

AB - Characterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38%) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38%), rheumatoid arthritis (RA, 21%), Sjögren's syndrome (18%), and primary biliary cirrhosis (4%). There were 260 (36%) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18%) and AITD (9%). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.jaut.2008.05.002

DO - 10.1016/j.jaut.2008.05.002

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JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

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Hudson M, Rojas-Villarraga A, Coral-Alvarado P, López-Guzmán S, Mantilla RD, Chalem P y otros. Polyautoimmunity and familial autoimmunity in systemic sclerosis. Journal of Autoimmunity. 2008 sep 1;156-159. https://doi.org/10.1016/j.jaut.2008.05.002