Pigment epithelium-derived factor: Clinical significance in estrogen-dependent tissues and its potential in cancer therapy

M.L. Franco-Chuaire, S. Ramírez-Clavijo, L. Chuaire-Noack

Resultado de la investigación: Contribución a RevistaArtículo

2 Citas (Scopus)

Resumen

© 2015, Mashhad University of Medical Sciences. All rights reserved.Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF.
Idioma originalEnglish (US)
Páginas (desde-hasta)837-855
Número de páginas19
PublicaciónIranian Journal of Basic Medical Sciences
Volumen18
N.º9
EstadoPublished - 2015

Huella dactilar

Estrogens
Tissue
Neoplasms
Therapeutics
Serpins
pigment epithelium-derived factor
Steroid Receptors
Bioactivity
Estrogen Receptors
Cell Survival
Glycoproteins
Genes
Cells
Cell Proliferation

Citar esto

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abstract = "{\circledC} 2015, Mashhad University of Medical Sciences. All rights reserved.Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF.",
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Pigment epithelium-derived factor: Clinical significance in estrogen-dependent tissues and its potential in cancer therapy. / Franco-Chuaire, M.L.; Ramírez-Clavijo, S.; Chuaire-Noack, L.

En: Iranian Journal of Basic Medical Sciences, Vol. 18, N.º 9, 2015, p. 837-855.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Pigment epithelium-derived factor: Clinical significance in estrogen-dependent tissues and its potential in cancer therapy

AU - Franco-Chuaire, M.L.

AU - Ramírez-Clavijo, S.

AU - Chuaire-Noack, L.

PY - 2015

Y1 - 2015

N2 - © 2015, Mashhad University of Medical Sciences. All rights reserved.Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF.

AB - © 2015, Mashhad University of Medical Sciences. All rights reserved.Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF.

M3 - Article

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JO - Iranian Journal of Basic Medical Sciences

JF - Iranian Journal of Basic Medical Sciences

SN - 2008-3866

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