TY - JOUR
T1 - Physiological and pathological implications of laminins
T2 - From the gene to the protein
AU - Páez, María Carolina
AU - González, María Julieta
AU - Serrano, Norma C.
AU - Shoenfeld, Yehuda
AU - Anaya, Juan Manuel
N1 - Funding Information:
This work was supported by Fundación para la Promoción de la Investigación y Tecnología, Bogotá (MCP, J-MA), Universidad Autónoma de Bucara-manga (MCP, NCS), Colombia and Fondecyt, 1050192, Chile (MJG).
Publisher Copyright:
© 2018, Taylor and Francis Ltd. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.
AB - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.
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U2 - 10.1080/08916930600911519
DO - 10.1080/08916930600911519
M3 - Article
C2 - 17453709
AN - SCOPUS:34250327154
SN - 0891-6934
VL - 40
SP - 83
EP - 94
JO - Autoimmunity
JF - Autoimmunity
IS - 2
ER -
