Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

Juan David Ramírez; María Clara Duque; Felipe Guhl

doi:10.1016/j.actatropica.2011.04.009

Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

Juan David Ramírez
, María Clara Duque
, Felipe Guhl

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

39 Citas (Scopus)

Resumen

Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	61-65
Número de páginas	5
Publicación	Acta Tropica
Volumen	119
N.º	1
DOI	https://doi.org/10.1016/j.actatropica.2011.04.009
Estado	Publicada - jul 2011
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Parasitología
Veterinaria (miscelánea)
Insectos
Enfermedades infecciosas

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10.1016/j.actatropica.2011.04.009

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title = "Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations",

abstract = "Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.",

author = "Ram{\'i}rez, \{Juan David\} and Duque, \{Mar{\'i}a Clara\} and Felipe Guhl",

note = "Funding Information: Financial support was provided by the Project Chagas EpiNet from The European Union Seventh Framework Programme, contract No. 223034. We thank the research fund of the faculty of sciences from the Universidad de los Andes and the group of parasitology from the Instituto Nacional de Salud in Colombia for providing some human isolates.",

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volume = "119",

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AU - Ramírez, Juan David

AU - Duque, María Clara

AU - Guhl, Felipe

N1 - Funding Information: Financial support was provided by the Project Chagas EpiNet from The European Union Seventh Framework Programme, contract No. 223034. We thank the research fund of the faculty of sciences from the Universidad de los Andes and the group of parasitology from the Instituto Nacional de Salud in Colombia for providing some human isolates.

PY - 2011/7

Y1 - 2011/7

N2 - Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

AB - Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

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U2 - 10.1016/j.actatropica.2011.04.009

DO - 10.1016/j.actatropica.2011.04.009

M3 - Research Article

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AN - SCOPUS:79957609164

SN - 0001-706X

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Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

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ODS de las Naciones Unidas

Áreas temáticas de ASJC Scopus

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