Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: A follow-up study

Sara C. Soto-De León, Luisa Del Río-Ospina, Milena Camargo, Ricardo Sánchez, Darwin A. Moreno-Pérez, Antonio Pérez-Prados, Manuel E. Patarroyo, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

11 Citas (Scopus)

Resumen

Background: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained.Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period).Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogotá had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95% CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95% CI) infection. Regarding viral load, HPV-45-infected women having 1 × 106 to 9.99 × 109 viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95% CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values.Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings. © 2014 Soto-De León et al.; licensee BioMed Central Ltd.
Idioma originalEnglish (US)
PublicaciónBMC Infectious Diseases
DOI
EstadoPublished - jul 16 2014

Huella dactilar

Viral Load
Colposcopy
Human papillomavirus 31
Human papillomavirus 16
Nonparametric Statistics
Infection
Human papillomavirus 6
Human papillomavirus 18
Colombia
Proportional Hazards Models
Delivery of Health Care
Survival

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Soto-De León, Sara C. ; Del Río-Ospina, Luisa ; Camargo, Milena ; Sánchez, Ricardo ; Moreno-Pérez, Darwin A. ; Pérez-Prados, Antonio ; Patarroyo, Manuel E. ; Patarroyo, Manuel A. / Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: A follow-up study. En: BMC Infectious Diseases. 2014.
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title = "Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: A follow-up study",
abstract = "Background: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained.Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period).Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogot{\'a} had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95{\%} CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95{\%} CI) infection. Regarding viral load, HPV-45-infected women having 1 × 106 to 9.99 × 109 viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95{\%} CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values.Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings. {\circledC} 2014 Soto-De Le{\'o}n et al.; licensee BioMed Central Ltd.",
author = "{Soto-De Le{\'o}n}, {Sara C.} and {Del R{\'i}o-Ospina}, Luisa and Milena Camargo and Ricardo S{\'a}nchez and Moreno-P{\'e}rez, {Darwin A.} and Antonio P{\'e}rez-Prados and Patarroyo, {Manuel E.} and Patarroyo, {Manuel A.}",
year = "2014",
month = "7",
day = "16",
doi = "10.1186/1471-2334-14-395",
language = "English (US)",
journal = "BMC Infectious Diseases",
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Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: A follow-up study. / Soto-De León, Sara C.; Del Río-Ospina, Luisa; Camargo, Milena; Sánchez, Ricardo; Moreno-Pérez, Darwin A.; Pérez-Prados, Antonio; Patarroyo, Manuel E.; Patarroyo, Manuel A.

En: BMC Infectious Diseases, 16.07.2014.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: A follow-up study

AU - Soto-De León, Sara C.

AU - Del Río-Ospina, Luisa

AU - Camargo, Milena

AU - Sánchez, Ricardo

AU - Moreno-Pérez, Darwin A.

AU - Pérez-Prados, Antonio

AU - Patarroyo, Manuel E.

AU - Patarroyo, Manuel A.

PY - 2014/7/16

Y1 - 2014/7/16

N2 - Background: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained.Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period).Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogotá had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95% CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95% CI) infection. Regarding viral load, HPV-45-infected women having 1 × 106 to 9.99 × 109 viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95% CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values.Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings. © 2014 Soto-De León et al.; licensee BioMed Central Ltd.

AB - Background: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained.Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period).Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogotá had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95% CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95% CI) infection. Regarding viral load, HPV-45-infected women having 1 × 106 to 9.99 × 109 viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95% CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values.Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings. © 2014 Soto-De León et al.; licensee BioMed Central Ltd.

U2 - 10.1186/1471-2334-14-395

DO - 10.1186/1471-2334-14-395

M3 - Article

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

ER -