Peptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates?

Manuel A. Patarroyo, Hernando Curtidor, David F. Plaza, Marisol Ocampo, Claudia Reyes, Obeimar Saboya, Gloria Barrera, Manuel E. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

9 Citas (Scopus)

Resumen

This study reports the Rv1490 gene presence and transcription in members of the Mycobacterium tuberculosis complex, and characterises the encoded Rv1490 putative membrane protein in M. tuberculosis H37Rv. Rv1490 derived peptides were synthesised and their A549 and U937 cell binding ability was tested, finding five high activity binding peptides (HABPs) for A549 and five for U937. Only two HABPs (11060 and 11073) were shared by both cell lines, both of which affected M. tuberculosis' invading ability to target cells, thus indicating an important role for these sequences in M. tuberculosis entry to A549 alveolar epithelial cells and supporting their inclusion in further studies on the development of a subunit-based multi-epitopic, chemically synthesised anti-tuberculosis vaccine. © 2008 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)4387-4395
Número de páginas9
PublicaciónVaccine
DOI
EstadoPublished - ago 12 2008

Huella dactilar

surface proteins
Mycobacterium tuberculosis
Membrane Proteins
epithelial cells
Vaccines
Epithelial Cells
peptides
vaccines
Peptides
Mycobacterium tuberculosis complex
Tuberculosis Vaccines
binding capacity
Alveolar Epithelial Cells
tuberculosis
membrane proteins
U937 Cells
transcription (genetics)
cell lines
cells
Cell Line

Citar esto

Patarroyo, Manuel A. ; Curtidor, Hernando ; Plaza, David F. ; Ocampo, Marisol ; Reyes, Claudia ; Saboya, Obeimar ; Barrera, Gloria ; Patarroyo, Manuel E. / Peptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates?. En: Vaccine. 2008 ; pp. 4387-4395.
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title = "Peptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates?",
abstract = "This study reports the Rv1490 gene presence and transcription in members of the Mycobacterium tuberculosis complex, and characterises the encoded Rv1490 putative membrane protein in M. tuberculosis H37Rv. Rv1490 derived peptides were synthesised and their A549 and U937 cell binding ability was tested, finding five high activity binding peptides (HABPs) for A549 and five for U937. Only two HABPs (11060 and 11073) were shared by both cell lines, both of which affected M. tuberculosis' invading ability to target cells, thus indicating an important role for these sequences in M. tuberculosis entry to A549 alveolar epithelial cells and supporting their inclusion in further studies on the development of a subunit-based multi-epitopic, chemically synthesised anti-tuberculosis vaccine. {\circledC} 2008 Elsevier Ltd. All rights reserved.",
author = "Patarroyo, {Manuel A.} and Hernando Curtidor and Plaza, {David F.} and Marisol Ocampo and Claudia Reyes and Obeimar Saboya and Gloria Barrera and Patarroyo, {Manuel E.}",
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Peptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates? / Patarroyo, Manuel A.; Curtidor, Hernando; Plaza, David F.; Ocampo, Marisol; Reyes, Claudia; Saboya, Obeimar; Barrera, Gloria; Patarroyo, Manuel E.

En: Vaccine, 12.08.2008, p. 4387-4395.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Patarroyo, Manuel A.

AU - Curtidor, Hernando

AU - Plaza, David F.

AU - Ocampo, Marisol

AU - Reyes, Claudia

AU - Saboya, Obeimar

AU - Barrera, Gloria

AU - Patarroyo, Manuel E.

PY - 2008/8/12

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AB - This study reports the Rv1490 gene presence and transcription in members of the Mycobacterium tuberculosis complex, and characterises the encoded Rv1490 putative membrane protein in M. tuberculosis H37Rv. Rv1490 derived peptides were synthesised and their A549 and U937 cell binding ability was tested, finding five high activity binding peptides (HABPs) for A549 and five for U937. Only two HABPs (11060 and 11073) were shared by both cell lines, both of which affected M. tuberculosis' invading ability to target cells, thus indicating an important role for these sequences in M. tuberculosis entry to A549 alveolar epithelial cells and supporting their inclusion in further studies on the development of a subunit-based multi-epitopic, chemically synthesised anti-tuberculosis vaccine. © 2008 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.vaccine.2008.05.092

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JF - Vaccine

SN - 0264-410X

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