Outcome of patients with autoimmune diseases in the intensive care unit: A mixed cluster analysis

Santiago Bernal-Macías, Benjamín Reyes-Beltrán, Nicolás Molano-González, Daniel Augusto Vega, Claudia Bichernall, Luis Aurelio Díaz, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

7 Citas (Scopus)

Resumen

Objectives: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. Methods: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. Results: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. Conclusions: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes.
Idioma originalEnglish (US)
PublicaciónLupus Science and Medicine
Volumen2
N.º1
DOI
EstadoPublished - 2015

Huella dactilar

Autoimmune Diseases
Intensive Care Units
Cluster Analysis
Survivors
Length of Stay
Fatal Outcome
Plasmapheresis
Mortality
Systemic Scleroderma
Secondary Prevention
Principal Component Analysis
Artificial Respiration
Tertiary Care Centers
Systemic Lupus Erythematosus
Shock
Sepsis
Infection

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Bernal-Macías, Santiago ; Reyes-Beltrán, Benjamín ; Molano-González, Nicolás ; Augusto Vega, Daniel ; Bichernall, Claudia ; Díaz, Luis Aurelio ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Outcome of patients with autoimmune diseases in the intensive care unit: A mixed cluster analysis. En: Lupus Science and Medicine. 2015 ; Vol. 2, N.º 1.
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abstract = "Objectives: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. Methods: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. Results: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45{\%} and 20{\%} of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36{\%} and 24{\%}, respectively. Mortality during ICU stay was 24{\%}. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. Conclusions: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes.",
author = "Santiago Bernal-Mac{\'i}as and Benjam{\'i}n Reyes-Beltr{\'a}n and Nicol{\'a}s Molano-Gonz{\'a}lez and {Augusto Vega}, Daniel and Claudia Bichernall and D{\'i}az, {Luis Aurelio} and Adriana Rojas-Villarraga and Anaya, {Juan Manuel}",
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Bernal-Macías, S, Reyes-Beltrán, B, Molano-González, N, Augusto Vega, D, Bichernall, C, Díaz, LA, Rojas-Villarraga, A & Anaya, JM 2015, 'Outcome of patients with autoimmune diseases in the intensive care unit: A mixed cluster analysis', Lupus Science and Medicine, vol. 2, n.º 1. https://doi.org/10.1136/lupus-2015-000122

Outcome of patients with autoimmune diseases in the intensive care unit: A mixed cluster analysis. / Bernal-Macías, Santiago; Reyes-Beltrán, Benjamín; Molano-González, Nicolás; Augusto Vega, Daniel; Bichernall, Claudia; Díaz, Luis Aurelio; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Lupus Science and Medicine, Vol. 2, N.º 1, 2015.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Outcome of patients with autoimmune diseases in the intensive care unit: A mixed cluster analysis

AU - Bernal-Macías, Santiago

AU - Reyes-Beltrán, Benjamín

AU - Molano-González, Nicolás

AU - Augusto Vega, Daniel

AU - Bichernall, Claudia

AU - Díaz, Luis Aurelio

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2015

Y1 - 2015

N2 - Objectives: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. Methods: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. Results: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. Conclusions: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes.

AB - Objectives: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. Methods: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. Results: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. Conclusions: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes.

U2 - 10.1136/lupus-2015-000122

DO - 10.1136/lupus-2015-000122

M3 - Article

VL - 2

JO - Lupus Science and Medicine

JF - Lupus Science and Medicine

SN - 2053-8790

IS - 1

ER -