Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231

Maribel Dolande-Franco; Diego H Caceres; Juan F Frey-Carrillo; Antoniellys Pérez-Guzmán; Andres Ceballos-Garzon; Aleiram Chaurio-Briceño; Bram Spruijtenburg; Yusely Roa-Díaz; Eelco F J Meijer; Elaine Cristina Francisco; Rodrigo Oliveira; Tatiana Drummond-Suinaga; Jacques F Meis

doi:10.3201/eid3206.251978

Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231

Título traducido de la contribución: Brote de infecciones del torrente sanguíneo por Wickerhamomyces anomalus (antes Candida pelliculosa), Venezuela, 2022-2023¹

Maribel Dolande-Franco
, Diego H Caceres
, Juan F Frey-Carrillo
, Antoniellys Pérez-Guzmán
, Andres Ceballos-Garzon
, Aleiram Chaurio-Briceño
, Bram Spruijtenburg
, Yusely Roa-Díaz
, Eelco F J Meijer
, Elaine Cristina Francisco
, Rodrigo Oliveira
, Tatiana Drummond-Suinaga
, Jacques F Meis

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

Resumen

Entre agosto de 2022 y diciembre de 2023, se identificaron un total de 110 infecciones del torrente sanguíneo causadas por Wickerhamomyces anomalus (sinónimo: Candida pelliculosa) en ocho hospitales de tres ciudades de Venezuela. La mayoría de los casos (82 de 110 en Caracas) se produjeron en una única unidad de cuidados intensivos pediátricos, principalmente entre neonatos. El genotipado molecular indicó múltiples eventos de transmisión clonal, lo que se vio respaldado por la agrupación epidemiológica de los pacientes. Las pruebas de sensibilidad a los antifúngicos demostraron una buena actividad in vitro; la mayoría de las cepas aisladas se clasificaron como de tipo salvaje. Nuestros hallazgos subrayan la necesidad de mejorar el diagnóstico fúngico, las medidas de prevención de infecciones y la vigilancia nacional para mitigar la transmisión fúngica asociada a los hospitales en entornos con recursos limitados.

Traducción realizada con la versión gratuita del traductor DeepL.com

Título traducido de la contribución	Brote de infecciones del torrente sanguíneo por Wickerhamomyces anomalus (antes Candida pelliculosa), Venezuela, 2022-2023¹
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	933-940
Número de páginas	8
Publicación	Emerging Infectious Diseases
Volumen	32
N.º	6
DOI	https://doi.org/10.3201/eid3206.251978
Estado	Publicación electrónica previa a su impresión - may 26 2026

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Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar
ODS 4: Educación de calidad

Áreas temáticas de ASJC Scopus

Microbiología (médica)

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Dolande-Franco, M., Caceres, D. H., Frey-Carrillo, J. F., Pérez-Guzmán, A., Ceballos-Garzon, A., Chaurio-Briceño, A., Spruijtenburg, B., Roa-Díaz, Y., Meijer, E. F. J., Francisco, E. C., Oliveira, R., Drummond-Suinaga, T., & Meis, J. F. (2026). Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231. Emerging Infectious Diseases, 32(6), 933-940. Avanzar publicación online. https://doi.org/10.3201/eid3206.251978

@article{edccbfa3b5194d608c29641bf55848cf,

title = "Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231",

abstract = "During August 2022-December 2023, a total of 110 bloodstream infections caused by Wickerhamomyces anomalus (synonym Candida pelliculosa) were identified across 8 hospitals in 3 cities in Venezuela. Most cases (82/110 in Caracas) occurred in a single pediatric intensive care unit, predominantly among neonates. Molecular genotyping indicated multiple events of clonal transmission, which was supported by epidemiologic clustering of patients. Antifungal susceptibility testing demonstrated good in vitro activity; most isolates were classified as wild-type. Our findings underscore the need for enhanced fungal diagnostics, infection prevention measures, and national surveillance to mitigate hospital-associated fungal transmission in resource-limited settings.",

author = "Maribel Dolande-Franco and Caceres, \{Diego H\} and Frey-Carrillo, \{Juan F\} and Antoniellys P{\'e}rez-Guzm{\'a}n and Andres Ceballos-Garzon and Aleiram Chaurio-Brice{\~n}o and Bram Spruijtenburg and Yusely Roa-D{\'i}az and Meijer, \{Eelco F J\} and Francisco, \{Elaine Cristina\} and Rodrigo Oliveira and Tatiana Drummond-Suinaga and Meis, \{Jacques F\}",

year = "2026",

month = may,

day = "26",

doi = "10.3201/eid3206.251978",

language = "English (US)",

volume = "32",

pages = "933--940",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "6",

}

Dolande-Franco, M, Caceres, DH, Frey-Carrillo, JF, Pérez-Guzmán, A, Ceballos-Garzon, A, Chaurio-Briceño, A, Spruijtenburg, B, Roa-Díaz, Y, Meijer, EFJ, Francisco, EC, Oliveira, R, Drummond-Suinaga, T & Meis, JF 2026, 'Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231', Emerging Infectious Diseases, vol. 32, n.º 6, pp. 933-940. https://doi.org/10.3201/eid3206.251978

TY - JOUR

T1 - Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231

AU - Dolande-Franco, Maribel

AU - Caceres, Diego H

AU - Frey-Carrillo, Juan F

AU - Pérez-Guzmán, Antoniellys

AU - Ceballos-Garzon, Andres

AU - Chaurio-Briceño, Aleiram

AU - Spruijtenburg, Bram

AU - Roa-Díaz, Yusely

AU - Meijer, Eelco F J

AU - Francisco, Elaine Cristina

AU - Oliveira, Rodrigo

AU - Drummond-Suinaga, Tatiana

AU - Meis, Jacques F

PY - 2026/5/26

Y1 - 2026/5/26

N2 - During August 2022-December 2023, a total of 110 bloodstream infections caused by Wickerhamomyces anomalus (synonym Candida pelliculosa) were identified across 8 hospitals in 3 cities in Venezuela. Most cases (82/110 in Caracas) occurred in a single pediatric intensive care unit, predominantly among neonates. Molecular genotyping indicated multiple events of clonal transmission, which was supported by epidemiologic clustering of patients. Antifungal susceptibility testing demonstrated good in vitro activity; most isolates were classified as wild-type. Our findings underscore the need for enhanced fungal diagnostics, infection prevention measures, and national surveillance to mitigate hospital-associated fungal transmission in resource-limited settings.

AB - During August 2022-December 2023, a total of 110 bloodstream infections caused by Wickerhamomyces anomalus (synonym Candida pelliculosa) were identified across 8 hospitals in 3 cities in Venezuela. Most cases (82/110 in Caracas) occurred in a single pediatric intensive care unit, predominantly among neonates. Molecular genotyping indicated multiple events of clonal transmission, which was supported by epidemiologic clustering of patients. Antifungal susceptibility testing demonstrated good in vitro activity; most isolates were classified as wild-type. Our findings underscore the need for enhanced fungal diagnostics, infection prevention measures, and national surveillance to mitigate hospital-associated fungal transmission in resource-limited settings.

U2 - 10.3201/eid3206.251978

DO - 10.3201/eid3206.251978

M3 - Research Article

C2 - 42190154

SN - 1080-6040

VL - 32

SP - 933

EP - 940

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -

Outbreak of Wickerhamomyces anomalus (formerly Candida pelliculosa) Bloodstream Infections, Venezuela, 2022-20231

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