Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis

Carolina Barragán-Martínez, Cesar A. Speck-Hernández, Gladis Montoya-Ortiz, Rubén D. Mantilla, Juan Manuel Anaya, Adriana Rojas-Villarraga, Sudha Chaturvedi

Resultado de la investigación: Contribución a RevistaArtículo

63 Citas (Scopus)

Resumen

Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value
Idioma originalEnglish (US)
PublicaciónPLoS One
DOI
EstadoPublished - dic 19 2012

Huella dactilar

autoimmune diseases
systematic review
meta-analysis
Organic solvents
Autoimmune Diseases
Meta-Analysis
risk factors
Systemic Scleroderma
sclerosis
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
Publication Bias
Systemic Vasculitis
vasculitis
chemical compounds
Chemical compounds
PubMed
Epigenomics

Citar esto

Barragán-Martínez, C., Speck-Hernández, C. A., Montoya-Ortiz, G., Mantilla, R. D., Anaya, J. M., Rojas-Villarraga, A., & Chaturvedi, S. (2012). Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. PLoS One. https://doi.org/10.1371/journal.pone.0051506
Barragán-Martínez, Carolina ; Speck-Hernández, Cesar A. ; Montoya-Ortiz, Gladis ; Mantilla, Rubén D. ; Anaya, Juan Manuel ; Rojas-Villarraga, Adriana ; Chaturvedi, Sudha. / Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. En: PLoS One. 2012.
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title = "Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis",
abstract = "Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95{\%} confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95{\%} CI: 1.25-1.92; p-value",
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Barragán-Martínez, C, Speck-Hernández, CA, Montoya-Ortiz, G, Mantilla, RD, Anaya, JM, Rojas-Villarraga, A & Chaturvedi, S 2012, 'Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis', PLoS One. https://doi.org/10.1371/journal.pone.0051506

Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. / Barragán-Martínez, Carolina; Speck-Hernández, Cesar A.; Montoya-Ortiz, Gladis; Mantilla, Rubén D.; Anaya, Juan Manuel; Rojas-Villarraga, Adriana; Chaturvedi, Sudha.

En: PLoS One, 19.12.2012.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Barragán-Martínez, Carolina

AU - Speck-Hernández, Cesar A.

AU - Montoya-Ortiz, Gladis

AU - Mantilla, Rubén D.

AU - Anaya, Juan Manuel

AU - Rojas-Villarraga, Adriana

AU - Chaturvedi, Sudha

PY - 2012/12/19

Y1 - 2012/12/19

N2 - Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value

AB - Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value

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Barragán-Martínez C, Speck-Hernández CA, Montoya-Ortiz G, Mantilla RD, Anaya JM, Rojas-Villarraga A y otros. Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. PLoS One. 2012 dic 19. https://doi.org/10.1371/journal.pone.0051506