Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort

Carlos Cifuentes-González; Pilar Uribe-Reina; Juliana Reyes-Guanes; Juliana Muñoz-Ortiz; Paula Tatiana Muñoz-Vargas; William Rojas-Carabali; Dora Victoria Nova-Florián; Ana Sofía De-Los-ríos; Rubén Dario Mantilla-Hernández; Alejandra De-La-torre

doi:10.2147/OPTH.S361243

Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort

Título traducido de la contribución: Manifestaciones oculares relacionadas con la positividad de anticuerpos y biomarcadores inflamatorios en una cohorte reumatológica

Carlos Cifuentes-González, Pilar Uribe-Reina, Juliana Reyes-Guanes, Juliana Muñoz-Ortiz, Paula Tatiana Muñoz-Vargas, William Rojas-Carabali, Dora Victoria Nova-Florián, Ana Sofía De-Los-ríos, Rubén Dario Mantilla-Hernández, Alejandra De-La-torre

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

Finalidad: La afectación ocular es frecuente en enfermedades autoinmunes e incluso puede ser la primera manifestación. Existen múltiples descripciones en la literatura alrededor del mundo sobre este tema. Sin embargo, evidenciamos una falta de estudios que analicen la relación entre las manifestaciones oculares y los biomarcadores sistémicos, especialmente en América Latina. Por lo tanto, este estudio tuvo como objetivo examinar la relación entre la positividad de los biomarcadores inflamatorios y las manifestaciones oculares en una cohorte colombiana de pacientes reumatológicos.
Pacientes y Métodos: Realizamos un estudio observacional, descriptivo, no comparativo, transversal en un centro de reumatología, en Bogotá, Colombia, del 2013 al 2019. Calculamos un tamaño de muestra de 797 pacientes para evaluar la prevalencia de manifestaciones oculares e inflamatorias. biomarcadores. Realizamos análisis univariados para variables categóricas y continuas y análisis bivariados mediante la prueba de Chi-cuadrado y exacta de Fisher para variables categóricas.
Resultados:Las mujeres representaron el 84% de la población y la edad media fue 54,61± 15,64 años. De 797 pacientes, el 21,45% reportó uno o más diagnósticos oftalmológicos, siendo la queratoconjuntivitis seca (KCS) la más común (15,93%), seguida de uveítis y cataratas (1,38%, cada una). En cuanto a los síntomas oftalmológicos, el 35% presentó al menos uno, siendo la sensación de ojo seco (ED) la más común (30,86%), seguida del dolor ocular (2,76%), ojo rojo y disminución de la agudeza visual (2,63%, cada uno). Los anticuerpos o biomarcadores inflamatorios encontrados con mayor frecuencia fueron los anticuerpos antinucleares (ANA) (35,3%), la proteína C reactiva (28,7%) y el factor reumatoide (27,9%). Encontramos asociaciones estadísticas entre el consumo de complemento 3, anticuerpos anti-CCP, anti-RO y anti-LA con manifestaciones oculares como fotofobia, DE, conjuntivitis, KCS, uveítis, vasculitis retiniana y maculopatía.
Conclusión: Las manifestaciones oculares se encuentran con frecuencia en pacientes con anticuerpos y biomarcadores inflamatorios positivos. Nuestros resultados sugieren que los anticuerpos y las moléculas inflamatorias podrían ser biomarcadores de manifestaciones oculares en pacientes con enfermedades reumatológicas. Este estudio proporciona la base para futuros estudios longitudinales.

Palabras clave: anticuerpos, biomarcador inflamatorio, enfermedad reumatológica, manifestaciones oculares, oftalmología, enfermedades autoinmunes.

Título traducido de la contribución	Manifestaciones oculares relacionadas con la positividad de anticuerpos y biomarcadores inflamatorios en una cohorte reumatológica
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	2477-2490
Número de páginas	14
Publicación	Clinical Ophthalmology
Volumen	16
DOI	https://doi.org/10.2147/OPTH.S361243
Estado	Publicada - ago. 9 2022

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Oftalmología

ODS de las Naciones Unidas

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Cifuentes-González, C., Uribe-Reina, P., Reyes-Guanes, J., Muñoz-Ortiz, J., Muñoz-Vargas, P. T., Rojas-Carabali, W., Nova-Florián, D. V., De-Los-ríos, A. S., Mantilla-Hernández, R. D., & De-La-torre, A. (2022). Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort. Clinical Ophthalmology, 16, 2477-2490. https://doi.org/10.2147/OPTH.S361243

@article{968249c208174e1a87a894cf7d5e6aad,

title = "Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort",

abstract = "Purpose: Ocular involvement is frequent in autoimmune diseases and even can be the first manifestation. There are multiple descriptions in the literature around the world regarding this topic. However, we evidenced a lack of studies analyzing the relationship between the ocular manifestations and systemic biomarkers, especially in Latinamerica. Therefore, this study aimed to examine the relationship between the positivity of inflammatory biomarkers and the ocular manifestations in a Colombian cohort of rheumatological patients. Patients and Methods: We conducted an observational, descriptive, non-comparative cross-sectional study in a rheumatology center, in Bogot{\'a}, Colombia, from 2013 to 2019. We calculated a sample size of 797 patients to assess the prevalence of ocular manifestations and inflammatory biomarkers. We performed univariate analyses for categorical and continuous variables and bivariate analyses using the Chi-square and Fisher{\textquoteright}s exact test for categorical variables. Results: Women represented 84% of the population, and the mean age was 54.61± 15.64 years. Of 797 patients, 21.45% reported one or more ophthalmological diagnoses, being keratoconjunctivitis sicca (KCS) the most common (15.93%), followed by uveitis, and cataract (1.38%, each one). Regarding ophthalmological symptoms, 35% presented at least one, being dry eye sensation (DE) the most common (30.86%), followed by ocular pain (2.76%), red eye, and decreased visual acuity (2.63%, each one). The antibodies or inflammatory biomarkers most frequently found were antinuclear antibodies (ANAs) (35.3%), C-reactive protein (28.7%), and rheumatoid factor (27.9%). We found statistical associations between consumption of complement 3, anti-CCP, anti-RO, and anti-LA antibodies with ocular manifestations such as photophobia, DE, conjunctivitis, KCS, uveitis, retinal vasculitis, and maculopathy. Conclusion: Ocular manifestations are frequently found in patients with positive antibodies and inflammatory biomarkers. Our results suggest antibodies and inflammatory molecules could be biomarkers for ocular manifestations in patients with rheumatological diseases. This study provides the basis for future longitudinal studies.",

author = "Carlos Cifuentes-Gonz{\'a}lez and Pilar Uribe-Reina and Juliana Reyes-Guanes and Juliana Mu{\~n}oz-Ortiz and Mu{\~n}oz-Vargas, {Paula Tatiana} and William Rojas-Carabali and Nova-Flori{\'a}n, {Dora Victoria} and De-Los-r{\'i}os, {Ana Sof{\'i}a} and Mantilla-Hern{\'a}ndez, {Rub{\'e}n Dario} and Alejandra De-La-torre",

note = "Publisher Copyright: {\textcopyright} 2022 Cifuentes-Gonz{\'a}lez et al.",

year = "2022",

month = aug,

day = "9",

doi = "10.2147/OPTH.S361243",

language = "English (US)",

volume = "16",

pages = "2477--2490",

journal = "Clinical Ophthalmology",

issn = "1177-5467",

publisher = "Dove Medical Press Ltd.",

}

Cifuentes-González, C, Uribe-Reina, P, Reyes-Guanes, J, Muñoz-Ortiz, J, Muñoz-Vargas, PT, Rojas-Carabali, W, Nova-Florián, DV, De-Los-ríos, AS, Mantilla-Hernández, RD & De-La-torre, A 2022, 'Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort', Clinical Ophthalmology, vol. 16, pp. 2477-2490. https://doi.org/10.2147/OPTH.S361243

TY - JOUR

T1 - Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort

AU - Cifuentes-González, Carlos

AU - Uribe-Reina, Pilar

AU - Reyes-Guanes, Juliana

AU - Muñoz-Ortiz, Juliana

AU - Muñoz-Vargas, Paula Tatiana

AU - Rojas-Carabali, William

AU - Nova-Florián, Dora Victoria

AU - De-Los-ríos, Ana Sofía

AU - Mantilla-Hernández, Rubén Dario

AU - De-La-torre, Alejandra

PY - 2022/8/9

Y1 - 2022/8/9

N2 - Purpose: Ocular involvement is frequent in autoimmune diseases and even can be the first manifestation. There are multiple descriptions in the literature around the world regarding this topic. However, we evidenced a lack of studies analyzing the relationship between the ocular manifestations and systemic biomarkers, especially in Latinamerica. Therefore, this study aimed to examine the relationship between the positivity of inflammatory biomarkers and the ocular manifestations in a Colombian cohort of rheumatological patients. Patients and Methods: We conducted an observational, descriptive, non-comparative cross-sectional study in a rheumatology center, in Bogotá, Colombia, from 2013 to 2019. We calculated a sample size of 797 patients to assess the prevalence of ocular manifestations and inflammatory biomarkers. We performed univariate analyses for categorical and continuous variables and bivariate analyses using the Chi-square and Fisher’s exact test for categorical variables. Results: Women represented 84% of the population, and the mean age was 54.61± 15.64 years. Of 797 patients, 21.45% reported one or more ophthalmological diagnoses, being keratoconjunctivitis sicca (KCS) the most common (15.93%), followed by uveitis, and cataract (1.38%, each one). Regarding ophthalmological symptoms, 35% presented at least one, being dry eye sensation (DE) the most common (30.86%), followed by ocular pain (2.76%), red eye, and decreased visual acuity (2.63%, each one). The antibodies or inflammatory biomarkers most frequently found were antinuclear antibodies (ANAs) (35.3%), C-reactive protein (28.7%), and rheumatoid factor (27.9%). We found statistical associations between consumption of complement 3, anti-CCP, anti-RO, and anti-LA antibodies with ocular manifestations such as photophobia, DE, conjunctivitis, KCS, uveitis, retinal vasculitis, and maculopathy. Conclusion: Ocular manifestations are frequently found in patients with positive antibodies and inflammatory biomarkers. Our results suggest antibodies and inflammatory molecules could be biomarkers for ocular manifestations in patients with rheumatological diseases. This study provides the basis for future longitudinal studies.

AB - Purpose: Ocular involvement is frequent in autoimmune diseases and even can be the first manifestation. There are multiple descriptions in the literature around the world regarding this topic. However, we evidenced a lack of studies analyzing the relationship between the ocular manifestations and systemic biomarkers, especially in Latinamerica. Therefore, this study aimed to examine the relationship between the positivity of inflammatory biomarkers and the ocular manifestations in a Colombian cohort of rheumatological patients. Patients and Methods: We conducted an observational, descriptive, non-comparative cross-sectional study in a rheumatology center, in Bogotá, Colombia, from 2013 to 2019. We calculated a sample size of 797 patients to assess the prevalence of ocular manifestations and inflammatory biomarkers. We performed univariate analyses for categorical and continuous variables and bivariate analyses using the Chi-square and Fisher’s exact test for categorical variables. Results: Women represented 84% of the population, and the mean age was 54.61± 15.64 years. Of 797 patients, 21.45% reported one or more ophthalmological diagnoses, being keratoconjunctivitis sicca (KCS) the most common (15.93%), followed by uveitis, and cataract (1.38%, each one). Regarding ophthalmological symptoms, 35% presented at least one, being dry eye sensation (DE) the most common (30.86%), followed by ocular pain (2.76%), red eye, and decreased visual acuity (2.63%, each one). The antibodies or inflammatory biomarkers most frequently found were antinuclear antibodies (ANAs) (35.3%), C-reactive protein (28.7%), and rheumatoid factor (27.9%). We found statistical associations between consumption of complement 3, anti-CCP, anti-RO, and anti-LA antibodies with ocular manifestations such as photophobia, DE, conjunctivitis, KCS, uveitis, retinal vasculitis, and maculopathy. Conclusion: Ocular manifestations are frequently found in patients with positive antibodies and inflammatory biomarkers. Our results suggest antibodies and inflammatory molecules could be biomarkers for ocular manifestations in patients with rheumatological diseases. This study provides the basis for future longitudinal studies.

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JO - Clinical Ophthalmology

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Ocular Manifestations Related to Antibodies Positivity and Inflammatory Biomarkers in a Rheumatological Cohort

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