Occupational exposures and mammographic density in Spanish women

Título traducido de la contribución: Exposiciones ocupacionales y densidad mamográfica en mujeres españolas

Virginia Lope, Javier García-Pérez, Beatriz Pérez-Gómez, Ana María Pedraza-Flechas, Juan Alguacil, Mª Carmen González-Galarzo, Miguel Angel Alba, Rudolf van der Haar, Rosa Ana Cortés-Barragán, Carmen Pedraz-Pingarrón, Pilar Moreo, Carmen Santamariña, María Ederra, Carmen Vidal, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Marina Pollán

Resultado de la investigación: Contribución a una revistaArtículo

3 Citas (Scopus)

Resumen

OBJETIVOS: La asociación entre las exposiciones ocupacionales y la densidad mamográfica (DM), un marcador del riesgo de cáncer de mama, no ha sido explorada previamente. Nuestro objetivo era investigar la influencia de la exposición ocupacional a agentes químicos, físicos y microbiológicos sobre la DM en mujeres adultas.

MÉTODOS: Se trata de un estudio transversal poblacional basado en 1476 mujeres trabajadoras de 45-65 años de edad de siete programas españoles de cribado del cáncer de mama. La historia ocupacional fue estudiada por personal capacitado. La exposición a agentes ocupacionales se evaluó mediante la matriz española de exposición laboral MatEmESp. El porcentaje de DM fue medido por dos radiólogos usando una herramienta computarizada semiautomática. La asociación se estimó mediante modelos de regresión logarítmicos mixtos que se ajustaron por edad, educación, índice de masa corporal, estado menopáusico, paridad, tabaquismo, ingesta de alcohol, tipo de mamografía, antecedentes familiares de cáncer de mama y uso de terapia hormonal, e incluyeron como términos de efectos aleatorios el centro de cribado y el lector profesional.

RESULTADOS: Aunque no se encontró asociación con la mayoría de los agentes, las mujeres expuestas ocupacionalmente al percloroetileno (eβ=1,51; IC del 95%: 1,04 a 2,19), a la radiación ionizante (eβ=1,23; IC del 95%: 0,99 a 1,52) y a las esporas de moho (eβ=1,44; IC del 95%: 1,01 a 2,04) tendieron a tener una mayor DM. El porcentaje de densidad aumentó un 12% por cada 5 años de exposición a percloroetileno o esporas de moho, un 11% por cada 5 años de exposición a disolventes de hidrocarburos alifáticos/alicíclicos y un 3% por cada 5 años de exposición a radiaciones ionizantes.

CONCLUSIONES: La exposición al percloroetileno, las radiaciones ionizantes, las esporas de moho o los disolventes de hidrocarburos alifáticos/alicíclicos en el lugar de trabajo podrían estar asociados con una mayor DM. Se necesitan estudios adicionales para aclarar la exactitud y las razones de estos hallazgos.
Idioma originalInglés estadounidense
Páginas (desde-hasta)124-131
Número de páginas8
PublicaciónOccupational and Environmental Medicine
Volumen75
N.º2
DOI
EstadoPublicada - feb 2018

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Lope, V., García-Pérez, J., Pérez-Gómez, B., Pedraza-Flechas, A. M., Alguacil, J., González-Galarzo, M. C., ... Pollán, M. (2018). Occupational exposures and mammographic density in Spanish women. Occupational and Environmental Medicine, 75(2), 124-131. https://doi.org/10.1136/oemed-2017-104580
Lope, Virginia ; García-Pérez, Javier ; Pérez-Gómez, Beatriz ; Pedraza-Flechas, Ana María ; Alguacil, Juan ; González-Galarzo, Mª Carmen ; Alba, Miguel Angel ; van der Haar, Rudolf ; Cortés-Barragán, Rosa Ana ; Pedraz-Pingarrón, Carmen ; Moreo, Pilar ; Santamariña, Carmen ; Ederra, María ; Vidal, Carmen ; Salas-Trejo, Dolores ; Sánchez-Contador, Carmen ; Llobet, Rafael ; Pollán, Marina. / Occupational exposures and mammographic density in Spanish women. En: Occupational and Environmental Medicine. 2018 ; Vol. 75, N.º 2. pp. 124-131.
@article{d2eed2bb7c304caa80ce884b19275e88,
title = "Occupational exposures and mammographic density in Spanish women",
abstract = "OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.RESULTS: Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (eβ=1.51; 95{\%} CI 1.04 to 2.19), ionising radiation (eβ=1.23; 95{\%} CI 0.99 to 1.52) and mould spores (eβ=1.44; 95{\%} CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12{\%} for every 5 years exposure to perchloroethylene or mould spores, 11{\%} for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3{\%} for each 5 years exposure to ionising radiation.CONCLUSIONS: Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.",
author = "Virginia Lope and Javier Garc{\'i}a-P{\'e}rez and Beatriz P{\'e}rez-G{\'o}mez and Pedraza-Flechas, {Ana Mar{\'i}a} and Juan Alguacil and Gonz{\'a}lez-Galarzo, {Mª Carmen} and Alba, {Miguel Angel} and {van der Haar}, Rudolf and Cort{\'e}s-Barrag{\'a}n, {Rosa Ana} and Carmen Pedraz-Pingarr{\'o}n and Pilar Moreo and Carmen Santamari{\~n}a and Mar{\'i}a Ederra and Carmen Vidal and Dolores Salas-Trejo and Carmen S{\'a}nchez-Contador and Rafael Llobet and Marina Poll{\'a}n",
note = "{\circledC} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2018",
month = "2",
doi = "10.1136/oemed-2017-104580",
language = "English (US)",
volume = "75",
pages = "124--131",
journal = "Occupational and Environmental Medicine",
issn = "1351-0711",
publisher = "BMJ Publishing Group",
number = "2",

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Lope, V, García-Pérez, J, Pérez-Gómez, B, Pedraza-Flechas, AM, Alguacil, J, González-Galarzo, MC, Alba, MA, van der Haar, R, Cortés-Barragán, RA, Pedraz-Pingarrón, C, Moreo, P, Santamariña, C, Ederra, M, Vidal, C, Salas-Trejo, D, Sánchez-Contador, C, Llobet, R & Pollán, M 2018, 'Occupational exposures and mammographic density in Spanish women', Occupational and Environmental Medicine, vol. 75, n.º 2, pp. 124-131. https://doi.org/10.1136/oemed-2017-104580

Occupational exposures and mammographic density in Spanish women. / Lope, Virginia; García-Pérez, Javier; Pérez-Gómez, Beatriz; Pedraza-Flechas, Ana María; Alguacil, Juan; González-Galarzo, Mª Carmen; Alba, Miguel Angel; van der Haar, Rudolf; Cortés-Barragán, Rosa Ana; Pedraz-Pingarrón, Carmen; Moreo, Pilar; Santamariña, Carmen; Ederra, María; Vidal, Carmen; Salas-Trejo, Dolores; Sánchez-Contador, Carmen; Llobet, Rafael; Pollán, Marina.

En: Occupational and Environmental Medicine, Vol. 75, N.º 2, 02.2018, p. 124-131.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Occupational exposures and mammographic density in Spanish women

AU - Lope, Virginia

AU - García-Pérez, Javier

AU - Pérez-Gómez, Beatriz

AU - Pedraza-Flechas, Ana María

AU - Alguacil, Juan

AU - González-Galarzo, Mª Carmen

AU - Alba, Miguel Angel

AU - van der Haar, Rudolf

AU - Cortés-Barragán, Rosa Ana

AU - Pedraz-Pingarrón, Carmen

AU - Moreo, Pilar

AU - Santamariña, Carmen

AU - Ederra, María

AU - Vidal, Carmen

AU - Salas-Trejo, Dolores

AU - Sánchez-Contador, Carmen

AU - Llobet, Rafael

AU - Pollán, Marina

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/2

Y1 - 2018/2

N2 - OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.RESULTS: Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (eβ=1.51; 95% CI 1.04 to 2.19), ionising radiation (eβ=1.23; 95% CI 0.99 to 1.52) and mould spores (eβ=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation.CONCLUSIONS: Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.

AB - OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women.METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms.RESULTS: Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (eβ=1.51; 95% CI 1.04 to 2.19), ionising radiation (eβ=1.23; 95% CI 0.99 to 1.52) and mould spores (eβ=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation.CONCLUSIONS: Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.

U2 - 10.1136/oemed-2017-104580

DO - 10.1136/oemed-2017-104580

M3 - Article

C2 - 29074552

VL - 75

SP - 124

EP - 131

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 2

ER -

Lope V, García-Pérez J, Pérez-Gómez B, Pedraza-Flechas AM, Alguacil J, González-Galarzo MC y otros. Occupational exposures and mammographic density in Spanish women. Occupational and Environmental Medicine. 2018 feb;75(2):124-131. https://doi.org/10.1136/oemed-2017-104580