Novel risk factors for cardiovascular disease in rheumatoid arthritis

Jenny Amaya-Amaya, Juan Camilo Sarmiento-Monroy, Ruben Dario Mantilla, Ricardo Pineda-Tamayo, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

26 Citas (Scopus)

Resumen

Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. © 2013 Springer Science+Business Media New York.
Idioma originalEnglish (US)
Páginas (desde-hasta)267-286
Número de páginas20
PublicaciónImmunologic Research
DOI
EstadoPublished - jul 1 2013

Huella dactilar

Rheumatoid Arthritis
Cardiovascular Diseases
Autoimmunity
Abdominal Obesity
Hypercholesterolemia
PubMed
Type 2 Diabetes Mellitus
Meta-Analysis
Decision Making
Body Mass Index
Research Design
Cross-Sectional Studies
Smoking
Steroids
Databases
Guidelines
Education
Mortality
Health
Population

Citar esto

Amaya-Amaya, J., Sarmiento-Monroy, J. C., Mantilla, R. D., Pineda-Tamayo, R., Rojas-Villarraga, A., & Anaya, J. M. (2013). Novel risk factors for cardiovascular disease in rheumatoid arthritis. Immunologic Research, 267-286. https://doi.org/10.1007/s12026-013-8398-7
Amaya-Amaya, Jenny ; Sarmiento-Monroy, Juan Camilo ; Mantilla, Ruben Dario ; Pineda-Tamayo, Ricardo ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Novel risk factors for cardiovascular disease in rheumatoid arthritis. En: Immunologic Research. 2013 ; pp. 267-286.
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abstract = "Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. {\circledC} 2013 Springer Science+Business Media New York.",
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Amaya-Amaya, J, Sarmiento-Monroy, JC, Mantilla, RD, Pineda-Tamayo, R, Rojas-Villarraga, A & Anaya, JM 2013, 'Novel risk factors for cardiovascular disease in rheumatoid arthritis', Immunologic Research, pp. 267-286. https://doi.org/10.1007/s12026-013-8398-7

Novel risk factors for cardiovascular disease in rheumatoid arthritis. / Amaya-Amaya, Jenny; Sarmiento-Monroy, Juan Camilo; Mantilla, Ruben Dario; Pineda-Tamayo, Ricardo; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Immunologic Research, 01.07.2013, p. 267-286.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Novel risk factors for cardiovascular disease in rheumatoid arthritis

AU - Amaya-Amaya, Jenny

AU - Sarmiento-Monroy, Juan Camilo

AU - Mantilla, Ruben Dario

AU - Pineda-Tamayo, Ricardo

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. © 2013 Springer Science+Business Media New York.

AB - Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. © 2013 Springer Science+Business Media New York.

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DO - 10.1007/s12026-013-8398-7

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SP - 267

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JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

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Amaya-Amaya J, Sarmiento-Monroy JC, Mantilla RD, Pineda-Tamayo R, Rojas-Villarraga A, Anaya JM. Novel risk factors for cardiovascular disease in rheumatoid arthritis. Immunologic Research. 2013 jul 1;267-286. https://doi.org/10.1007/s12026-013-8398-7