Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

Amit K. Maiti, Xana Kim-Howard, Parvathi Viswanathan, Laura Guillén, Xiaoxia Qian, Adriana Rojas-Villarraga, Celi Sun, Carlos Cañas, Gabriel J. Tobón, Koichi Matsuda, Nan Shen, Alejandra C. Cherñavsky, Juan Manuel Anaya, Swapan K. Nath

Resultado de la investigación: Contribución a RevistaArtículo

44 Citas (Scopus)

Resumen

Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.
Idioma originalEnglish (US)
Páginas (desde-hasta)1239-1244
Número de páginas6
PublicaciónRheumatology
DOI
EstadoPublished - mar 24 2010

Huella dactilar

Autoimmune Diseases
Odds Ratio
Population
Celiac Disease
Type 1 Diabetes Mellitus
Colombia
Argentina
Rheumatology
Autoimmunity
Genes
Single Nucleotide Polymorphism
Meta-Analysis
China
Japan

Citar esto

Maiti, A. K., Kim-Howard, X., Viswanathan, P., Guillén, L., Qian, X., Rojas-Villarraga, A., ... Nath, S. K. (2010). Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. Rheumatology, 1239-1244. https://doi.org/10.1093/rheumatology/kep470
Maiti, Amit K. ; Kim-Howard, Xana ; Viswanathan, Parvathi ; Guillén, Laura ; Qian, Xiaoxia ; Rojas-Villarraga, Adriana ; Sun, Celi ; Cañas, Carlos ; Tobón, Gabriel J. ; Matsuda, Koichi ; Shen, Nan ; Cherñavsky, Alejandra C. ; Anaya, Juan Manuel ; Nath, Swapan K. / Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. En: Rheumatology. 2010 ; pp. 1239-1244.
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title = "Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases",
abstract = "Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95{\%} CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. {\circledC} The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.",
author = "Maiti, {Amit K.} and Xana Kim-Howard and Parvathi Viswanathan and Laura Guill{\'e}n and Xiaoxia Qian and Adriana Rojas-Villarraga and Celi Sun and Carlos Ca{\~n}as and Tob{\'o}n, {Gabriel J.} and Koichi Matsuda and Nan Shen and Cher{\~n}avsky, {Alejandra C.} and Anaya, {Juan Manuel} and Nath, {Swapan K.}",
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doi = "10.1093/rheumatology/kep470",
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Maiti, AK, Kim-Howard, X, Viswanathan, P, Guillén, L, Qian, X, Rojas-Villarraga, A, Sun, C, Cañas, C, Tobón, GJ, Matsuda, K, Shen, N, Cherñavsky, AC, Anaya, JM & Nath, SK 2010, 'Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases', Rheumatology, pp. 1239-1244. https://doi.org/10.1093/rheumatology/kep470

Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. / Maiti, Amit K.; Kim-Howard, Xana; Viswanathan, Parvathi; Guillén, Laura; Qian, Xiaoxia; Rojas-Villarraga, Adriana; Sun, Celi; Cañas, Carlos; Tobón, Gabriel J.; Matsuda, Koichi; Shen, Nan; Cherñavsky, Alejandra C.; Anaya, Juan Manuel; Nath, Swapan K.

En: Rheumatology, 24.03.2010, p. 1239-1244.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

AU - Maiti, Amit K.

AU - Kim-Howard, Xana

AU - Viswanathan, Parvathi

AU - Guillén, Laura

AU - Qian, Xiaoxia

AU - Rojas-Villarraga, Adriana

AU - Sun, Celi

AU - Cañas, Carlos

AU - Tobón, Gabriel J.

AU - Matsuda, Koichi

AU - Shen, Nan

AU - Cherñavsky, Alejandra C.

AU - Anaya, Juan Manuel

AU - Nath, Swapan K.

PY - 2010/3/24

Y1 - 2010/3/24

N2 - Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.

AB - Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.

U2 - 10.1093/rheumatology/kep470

DO - 10.1093/rheumatology/kep470

M3 - Article

SP - 1239

EP - 1244

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

ER -

Maiti AK, Kim-Howard X, Viswanathan P, Guillén L, Qian X, Rojas-Villarraga A y otros. Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. Rheumatology. 2010 mar 24;1239-1244. https://doi.org/10.1093/rheumatology/kep470